Wellbutrin and Multi-organ failure - a phase IV clinical study of FDA data

Summary:

Multi-organ failure is reported as a side effect among people who take Wellbutrin (bupropion hydrochloride), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Alprazolam, and have High blood pressure.

The phase IV clinical study analyzes which people have Multi-organ failure when taking Wellbutrin. It is created by eHealthMe based on reports of 101,581 people who have side effects when taking Wellbutrin from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,115 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Multi-organ failure?

Multi-organ failure (multisystem organ failure) is found to be associated with 1,380 drugs and 2,281 conditions by eHealthMe. Check the latest studies of Multi-organ failure.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

101,581 people reported to have side effects when taking Wellbutrin.
Among them, 59 people (0.06%) have Multi-organ failure.

Could Wellbutrin cause Multi-organ failure?

Among these 59 people:

How long have people been on Wellbutrin when they have Multi-organ failure? *

What is the gender of people who have Multi-organ failure when taking Wellbutrin? *

female: 38.78 %
male: 61.22 %

What is the age of people who have Multi-organ failure when taking Wellbutrin? *

What are other drugs people take besides Wellbutrin? *

What are other side effects people have besides Multi-organ failure? *

Acute Kidney Failure: 40 people, 67.80%
Pain: 30 people, 50.85%
Sepsis (a severe blood infection that can lead to organ failure and death): 23 people, 38.98%
Hypotension (abnormally low blood pressure): 22 people, 37.29%
Fever: 22 people, 37.29%
Dehydration (dryness resulting from the removal of water): 18 people, 30.51%
Back Pain: 18 people, 30.51%
Rashes (redness): 18 people, 30.51%
Confusional State: 18 people, 30.51%
Abdominal Pain: 17 people, 28.81%

What are the existing conditions these people have? *

Breast Cancer: 15 people, 25.42%
Diabetes: 15 people, 25.42%
Metastases To Bone (cancer spreads to bone): 15 people, 25.42%
High Blood Pressure: 15 people, 25.42%
Bone Pain: 14 people, 23.73%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 5.08%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 3.39%
Multiple Myeloma (cancer of the plasma cells): 2 people, 3.39%
Back Pain: 2 people, 3.39%
Lung Cancer - Non-Small Cell (lung cancer): 2 people, 3.39%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin and have Multi-organ failure?

- Check whether Multi-organ failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Wellbutrin:

Wellbutrin (117,115 reports)

Browse all side effects of Wellbutrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multi-organ failure:

Multi-organ failure (1,380 drugs)

Browse all the conditions that are associated with Multi-organ failure:

Multi-organ failure (2,281 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride (the active ingredients of Wellbutrin) and Wellbutrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.