Wellbutrin and Muscle contracture - a phase IV clinical study of FDA data

Summary:

Muscle contracture is reported as a side effect among people who take Wellbutrin (bupropion hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months also take Lexapro, and have Bronchiectasis.

The phase IV clinical study analyzes which people have Muscle contracture when taking Wellbutrin. It is created by eHealthMe based on reports of 101,581 people who have side effects when taking Wellbutrin from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,110 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Muscle contracture?

Muscle contracture (a permanent shortening of a muscle) is found to be associated with 327 drugs and 525 conditions by eHealthMe. Check the latest studies of Muscle contracture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

101,581 people reported to have side effects when taking Wellbutrin.
Among them, 16 people (0.02%) have Muscle contracture.

Could Wellbutrin cause Muscle contracture?

Among these 16 people:

How long have people been on Wellbutrin when they have Muscle contracture? *

What is the gender of people who have Muscle contracture when taking Wellbutrin? *

female: 81.25 %
male: 18.75 %

What is the age of people who have Muscle contracture when taking Wellbutrin? *

What are other drugs people take besides Wellbutrin? *

What are other side effects people have besides Muscle contracture? *

Pain: 9 people, 56.25%
Muscle Spasms (muscle contraction): 6 people, 37.50%
Joint Pain: 4 people, 25.00%
Scar: 4 people, 25.00%
Skin Fibrosis (fibrous tissue formation on skin): 4 people, 25.00%
Mobility Decreased (ability to move is reduced): 4 people, 25.00%
Injury: 4 people, 25.00%
Nephrogenic Systemic Fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease): 4 people, 25.00%
Fatigue (feeling of tiredness): 4 people, 25.00%
Emotional Distress: 4 people, 25.00%

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 2 people, 12.50%
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection): 2 people, 12.50%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 6.25%
Weight Decreased: 1 person, 6.25%
Osteoporosis (bones weak and more likely to break): 1 person, 6.25%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.25%
Immunodeficiency Common Variable: 1 person, 6.25%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 6.25%
High Blood Pressure: 1 person, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin and have Muscle contracture?

- Check whether Muscle contracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Wellbutrin:

Wellbutrin (117,110 reports)

Browse all side effects of Wellbutrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle contracture:

Muscle contracture (327 drugs)

Browse all the conditions that are associated with Muscle contracture:

Muscle contracture (525 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride (the active ingredients of Wellbutrin) and Wellbutrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.