Wellbutrin and Necrosis - a phase IV clinical study of FDA data

Summary:

Necrosis is reported as a side effect among people who take Wellbutrin (bupropion hydrochloride), especially for people who are male, 30-39 old, have been taking the drug for 2 - 5 years also take Zyban, and have High blood pressure.

The phase IV clinical study analyzes which people have Necrosis when taking Wellbutrin. It is created by eHealthMe based on reports of 101,581 people who have side effects when taking Wellbutrin from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,110 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Necrosis?

Necrosis (the death of body tissue) is found to be associated with 750 drugs and 970 conditions by eHealthMe. Check the latest studies of Necrosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

101,581 people reported to have side effects when taking Wellbutrin.
Among them, 34 people (0.03%) have Necrosis.

Among these 34 people:

How long have people been on Wellbutrin when they have Necrosis? *

What is the gender of people who have Necrosis when taking Wellbutrin? *

female: 41.38 %
male: 58.62 %

What is the age of people who have Necrosis when taking Wellbutrin? *

What are other drugs people take besides Wellbutrin? *

What are other side effects people have besides Necrosis? *

Fatigue (feeling of tiredness): 6 people, 17.65%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 17.65%
Wound: 5 people, 14.71%
Cataract (clouding of the lens inside the eye): 5 people, 14.71%
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle): 4 people, 11.76%
Head Injury: 4 people, 11.76%
Pain: 4 people, 11.76%
Osteomyelitis (infection of bone): 4 people, 11.76%
Diarrhea: 4 people, 11.76%
Dyspnea (difficult or laboured breathing): 3 people, 8.82%

What are the existing conditions these people have? *

Pain: 3 people, 8.82%
High Blood Pressure: 3 people, 8.82%
Burkitt Lymphoma (cancer of the lymphatic system): 2 people, 5.88%
Multiple Myeloma (cancer of the plasma cells): 2 people, 5.88%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 5.88%
Diabetes: 2 people, 5.88%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 5.88%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 5.88%
Osteoporosis (bones weak and more likely to break): 2 people, 5.88%
Sleep Disorder: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin and have Necrosis?

- Check whether Necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Wellbutrin:

Wellbutrin (117,110 reports)

Necrosis treatments and more:

Necrosis (8,274 reports)

Browse all side effects of Wellbutrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Necrosis:

Necrosis (750 drugs)

Browse all the conditions that are associated with Necrosis:

Necrosis (970 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride (the active ingredients of Wellbutrin) and Wellbutrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.