Xcopri and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Xcopri (cenobamate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Keppra, and have Seizures.

The phase IV clinical study analyzes which people have Depression when taking Xcopri. It is created by eHealthMe based on reports of 4,132 people who have side effects when taking Xcopri from the FDA, and is updated regularly.

What is Xcopri?

Xcopri has active ingredients of cenobamate. eHealthMe is studying from 4,142 Xcopri users. Check the latest studies of Xcopri.

What is Depression?

Depression is found to be associated with 3,168 drugs and 4,125 conditions by eHealthMe. Check the latest studies of Depression.

On Jul, 16, 2026

4,132 people reported to have side effects when taking Xcopri.
Among them, 76 people (1.84%) have Depression.

Among these 76 people:

How long have people been on Xcopri when they have Depression? *

What is the gender of people who have Depression when taking Xcopri? *

female: 60 %
male: 40 %

What is the age of people who have Depression when taking Xcopri? *

What are other drugs people take besides Xcopri? *

What are other side effects people have besides Depression? *

Fatigue (feeling of tiredness): 27 people, 35.53%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 20 people, 26.32%
Drowsiness: 19 people, 25.00%
Stress And Anxiety: 15 people, 19.74%
Suicidal Ideation: 14 people, 18.42%
Memory Loss: 11 people, 14.47%
Irritability: 10 people, 13.16%
Dizziness: 9 people, 11.84%
Weakness: 8 people, 10.53%
Fall: 8 people, 10.53%

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 43 people, 56.58%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 34 people, 44.74%
Partial Seizures (seizures which affect only a part of the brain at onset): 6 people, 7.89%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 2 people, 2.63%
Stress And Anxiety: 2 people, 2.63%
High Blood Pressure: 2 people, 2.63%
Hypersensitivity: 2 people, 2.63%
Insomnia (sleeplessness): 2 people, 2.63%
Mood Swings (an extreme or rapid change in mood): 2 people, 2.63%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 2 people, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Xcopri and have Depression?

- Check whether Depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xcopri:

Xcopri (4,142 reports)

Depression treatments and more:

Depression (652,144 reports)

Browse all side effects of Xcopri:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,168 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,125 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on cenobamate (the active ingredients of Xcopri) and Xcopri (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.