Xeljanz and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Xeljanz (tofacitinib citrate), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Enbrel, and have Psoriatic arthropathy.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Xeljanz. It is created by eHealthMe based on reports of 238,928 people who have side effects when taking Xeljanz from the FDA, and is updated regularly.

What is Xeljanz?

Xeljanz has active ingredients of tofacitinib citrate. It is often used in rheumatoid arthritis. eHealthMe is studying from 239,081 Xeljanz users. Check the latest studies of Xeljanz.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 953 drugs and 1,230 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 12, 2026

238,928 people reported to have side effects when taking Xeljanz.
Among them, 2,579 people (1.08%) have Knee joint replacement.

Could Xeljanz cause Knee joint replacement?

Among these 2,579 people:

How long have people been on Xeljanz when they have Knee joint replacement? *

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What is the gender of people who have Knee joint replacement when taking Xeljanz? *

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What is the age of people who have Knee joint replacement when taking Xeljanz? *

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* Approximation only. Some reports may have incomplete information.

Do you take Xeljanz and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xeljanz:

Xeljanz (239,081 reports)

Knee joint replacement treatments and more:

Knee joint replacement (26,755 reports)

How severe was Knee joint replacement and when was it recovered:

Knee joint replacement in Xeljanz

Expand to all the drugs that have ingredients of tofacitinib citrate:

Knee joint replacement and drugs with ingredients of tofacitinib citrate (2,633 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xeljanz:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (953 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,230 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tofacitinib citrate (the active ingredients of Xeljanz) and Xeljanz (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.