Xeljanz and Thyroid function test abnormal - a phase IV clinical study of FDA data

Summary:

Thyroid function test abnormal is reported as a side effect among people who take Xeljanz (tofacitinib citrate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Enbrel, and have Psoriatic arthropathy.

The phase IV clinical study analyzes which people have Thyroid function test abnormal when taking Xeljanz. It is created by eHealthMe based on reports of 238,928 people who have side effects when taking Xeljanz from the FDA, and is updated regularly.

What is Xeljanz?

Xeljanz has active ingredients of tofacitinib citrate. It is often used in rheumatoid arthritis. eHealthMe is studying from 239,081 Xeljanz users. Check the latest studies of Xeljanz.

What is Thyroid function test abnormal?

Thyroid function test abnormal is found to be associated with 1,705 drugs and 1,583 conditions by eHealthMe. Check the latest studies of Thyroid function test abnormal.

On Sep, 15, 2025

238,928 people reported to have side effects when taking Xeljanz.
Among them, 539 people (0.23%) have Thyroid function test abnormal.

Could Xeljanz cause Thyroid function test abnormal?

Among these 539 people:

How long have people been on Xeljanz when they have Thyroid function test abnormal? *

What is the gender of people who have Thyroid function test abnormal when taking Xeljanz? *

female: 92.21 %
male: 7.79 %

What is the age of people who have Thyroid function test abnormal when taking Xeljanz? *

What are other drugs people take besides Xeljanz? *

What are other side effects people have besides Thyroid function test abnormal? *

Drug Ineffective: 219 people, 40.63%
High Blood Pressure: 163 people, 30.24%
Drug Intolerance (drug sensitivity): 146 people, 27.09%
Nausea And Vomiting: 143 people, 26.53%
Pneumonia: 143 people, 26.53%
Drug Hypersensitivity: 138 people, 25.60%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 136 people, 25.23%
Hepatic Enzyme Increased: 135 people, 25.05%
Synovitis (inflammation of the synovial membrane): 131 people, 24.30%
Hypersensitivity: 131 people, 24.30%

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 48 people, 8.91%
Limb Discomfort (discomfort in leg): 28 people, 5.19%
Pneumonia: 26 people, 4.82%
High Blood Cholesterol: 11 people, 2.04%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 11 people, 2.04%
Pain: 9 people, 1.67%
Alopecia Areata (patchy baldness that typically begins with rapid hair loss): 8 people, 1.48%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 8 people, 1.48%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 8 people, 1.48%
Swelling: 7 people, 1.30%

* Approximation only. Some reports may have incomplete information.

Do you take Xeljanz and have Thyroid function test abnormal?

- Check whether Thyroid function test abnormal is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xeljanz:

Xeljanz (239,081 reports)

Common Xeljanz side effects:

Browse all side effects of Xeljanz:

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Common drugs associated with Thyroid function test abnormal:

Browse all the drugs that are associated with Thyroid function test abnormal:

Thyroid function test abnormal (1,705 drugs)

Common conditions associated with Thyroid function test abnormal:

Rheumatoid arthritis aggravated: 1,897 reports
Multiple sclerosis aggravated: 1,590 reports
High blood pressure: 1,297 reports
Thyroid disorder: 1,022 reports
Thyroid function test abnormal: 1,020 reports
Under active thyroid: 1,006 reports
Blood cholesterol abnormal: 848 reports
Blood triglycerides increased: 844 reports
Lipoprotein test: 797 reports
Osteoporosis: 789 reports

Browse all the conditions that are associated with Thyroid function test abnormal:

Thyroid function test abnormal (1,583 conditions)

Drugs similar to Xeljanz and Thyroid function test abnormal :

How the study uses the data?

The study uses data from the FDA. It is based on tofacitinib citrate (the active ingredients of Xeljanz) and Xeljanz (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.