Xenical and Glaucoma - a phase IV clinical study of FDA data


Glaucoma is found among people who take Xenical, especially for people who are female, 50-59 old, have been taking the drug for 1 - 2 years.

The phase IV clinical study analyzes which people take Xenical and have Glaucoma. It is created by eHealthMe based on reports of 11,510 people who have side effects when taking Xenical from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 19, 2022

11,510 people reported to have side effects when taking Xenical.
Among them, 9 people (0.08%) have Glaucoma.

What is Xenical?

Xenical has active ingredients of orlistat. It is often used in weight loss. eHealthMe is studying from 11,667 Xenical users for its effectiveness, alternative drugs and more.

What is Glaucoma?

Glaucoma (increased fluid pressure in the eye with vision loss) is found to be associated with 2,149 drugs and 1,514 conditions by eHealthMe.

Number of Xenical and Glaucoma reports submitted per year:

Could Xenical cause Glaucoma?

Time on Xenical when people have Glaucoma *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 100 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Glaucoma when taking Xenical *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Glaucoma when taking Xenical *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 20 %
  • 50-59: 60 %
  • 60+: 20 %

Common drugs people take besides Xenical *:

  1. Premarin: 5 people, 55.56%
  2. Zantac: 5 people, 55.56%
  3. Celebrex: 4 people, 44.44%
  4. Lasix: 4 people, 44.44%
  5. Paxil: 4 people, 44.44%
  6. Lotrisone: 3 people, 33.33%
  7. Timolol Maleate: 3 people, 33.33%
  8. Zyprexa: 3 people, 33.33%
  9. Erythromycin: 3 people, 33.33%
  10. Flexeril: 3 people, 33.33%

Common side effects people have besides Glaucoma *:

  1. Depression: 6 people, 66.67%
  2. Chest Pain: 4 people, 44.44%
  3. Swallowing Difficulty: 4 people, 44.44%
  4. High Blood Pressure: 4 people, 44.44%
  5. Weight Increased: 4 people, 44.44%
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 33.33%
  7. Insomnia (sleeplessness): 3 people, 33.33%
  8. Oedema (fluid collection in tissue): 3 people, 33.33%
  9. Hypoglycemia (low blood sugar): 3 people, 33.33%
  10. Basal Cell Carcinoma (a skin cancer, it rarely metastasizes or kills): 3 people, 33.33%

Common conditions people have *:

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 33.33%
  2. Bipolar Disorder (mood disorder): 3 people, 33.33%
  3. High Blood Pressure: 2 people, 22.22%
  4. Paget's Disease (disorder that involves abnormal bone destruction and regrowth, which results in deformity): 1 person, 11.11%
  5. Osteoporosis (bones weak and more likely to break): 1 person, 11.11%
  6. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 11.11%
  7. Muscle Spasms (muscle contraction): 1 person, 11.11%
  8. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 11.11%
  9. Intervertebral Disc Degeneration (spinal disc degeneration): 1 person, 11.11%
  10. Indigestion: 1 person, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Xenical and have Glaucoma?

Check whether Glaucoma is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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Expand to all the drugs that have ingredients of orlistat:

Alternative drugs to, pros and cons of Xenical:

Common Xenical side effects:

Browse all side effects of Xenical:

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Glaucoma treatments and more:

COVID vaccines that are related to Glaucoma:

Common drugs associated with Glaucoma:

All the drugs that are associated with Glaucoma:

Common conditions associated with Glaucoma:

All the conditions that are associated with Glaucoma:

How the study uses the data?

The study uses data from the FDA. It is based on orlistat (the active ingredients of Xenical) and Xenical (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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