Xifaxan and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Xifaxan (rifaximin), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Ativan, and have Narcolepsy.

The phase IV clinical study analyzes which people have Major depression when taking Xifaxan. It is created by eHealthMe based on reports of 16,409 people who have side effects when taking Xifaxan from the FDA, and is updated regularly.

What is Xifaxan?

Xifaxan has active ingredients of rifaximin. It is often used in irritable bowel syndrome. eHealthMe is studying from 16,609 Xifaxan users. Check the latest studies of Xifaxan.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 798 drugs and 1,478 conditions by eHealthMe. Check the latest studies of Major depression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

16,409 people reported to have side effects when taking Xifaxan.
Among them, 11 people (0.07%) have Major depression.

Among these 11 people:

How long have people been on Xifaxan when they have Major depression? *

What is the gender of people who have Major depression when taking Xifaxan? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Major depression when taking Xifaxan? *

What are other drugs people take besides Xifaxan? *

What are other side effects people have besides Major depression? *

Cough: 4 people, 36.36%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 4 people, 36.36%
Suicidal Ideation: 4 people, 36.36%
Memory Loss: 4 people, 36.36%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 4 people, 36.36%
Weight Increased: 3 people, 27.27%
Pain: 3 people, 27.27%
Clavicle Fracture: 3 people, 27.27%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 27.27%
Nausea (feeling of having an urge to vomit): 3 people, 27.27%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 36.36%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 27.27%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 9.09%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 9.09%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 9.09%
Pain: 1 person, 9.09%
Nausea (feeling of having an urge to vomit): 1 person, 9.09%
Liver Disorder (liver diseases): 1 person, 9.09%
Inflammatory Bowel Disease: 1 person, 9.09%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Xifaxan and have Major depression?

- Check whether Major depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xifaxan:

Xifaxan (16,609 reports)

Major depression treatments and more:

Major depression (44,987 reports)

Browse all side effects of Xifaxan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (798 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,478 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on rifaximin (the active ingredients of Xifaxan) and Xifaxan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.