Xifaxan and Speech disorder - a phase IV clinical study of FDA data

Summary:

Speech disorder is reported as a side effect among people who take Xifaxan (rifaximin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Protonix, and have Hepatic cirrhosis.

The phase IV clinical study analyzes which people have Speech disorder when taking Xifaxan. It is created by eHealthMe based on reports of 16,409 people who have side effects when taking Xifaxan from the FDA, and is updated regularly.

What is Xifaxan?

Xifaxan has active ingredients of rifaximin. It is often used in irritable bowel syndrome. eHealthMe is studying from 16,609 Xifaxan users. Check the latest studies of Xifaxan.

What is Speech disorder?

Speech disorder is found to be associated with 1,808 drugs and 2,279 conditions by eHealthMe. Check the latest studies of Speech disorder.



On Jul, 16, 2026

16,409 people reported to have side effects when taking Xifaxan.
Among them, 54 people (0.33%) have Speech disorder.

Could Xifaxan cause Speech disorder?

Among these 54 people:

How long have people been on Xifaxan when they have Speech disorder? *

  • < 1 month: 41.18 %
  • 1 - 6 months: 17.65 %
  • 6 - 12 months: 5.88 %
  • 1 - 2 years: 11.76 %
  • 2 - 5 years: 23.53 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Speech disorder when taking Xifaxan? *

  • female: 51.85 %
  • male: 48.15 %

What is the age of people who have Speech disorder when taking Xifaxan? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 5.13 %
  • 30-39: 5.13 %
  • 40-49: 2.56 %
  • 50-59: 12.82 %
  • 60+: 74.36 %

What are other drugs people take besides Xifaxan? *

  1. Lactulose: 6 people, 11.11%
  2. Protonix: 6 people, 11.11%
  3. Zofran: 5 people, 9.26%
  4. Ambien: 5 people, 9.26%
  5. Lasix: 5 people, 9.26%
  6. Proscar: 4 people, 7.41%
  7. Meloxicam: 4 people, 7.41%
  8. Misoprostol: 4 people, 7.41%
  9. Morphine: 4 people, 7.41%
  10. Multivitamin: 4 people, 7.41%

What are other side effects people have besides Speech disorder? *

  1. Ammonia Increased: 15 people, 27.78%
  2. Confusional State: 10 people, 18.52%
  3. Dyspnea (difficult or laboured breathing): 8 people, 14.81%
  4. Memory Loss: 7 people, 12.96%
  5. Fatigue (feeling of tiredness): 6 people, 11.11%
  6. Dizziness: 6 people, 11.11%
  7. Balance Disorder: 6 people, 11.11%
  8. Hepatic Failure (liver failure): 5 people, 9.26%
  9. Feeling Abnormal: 5 people, 9.26%
  10. Pain: 5 people, 9.26%

What are the existing conditions these people have? *

  1. Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 15 people, 27.78%
  2. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.41%
  3. Prostate Cancer Metastatic: 4 people, 7.41%
  4. Sleep Disorder: 3 people, 5.56%
  5. Pain: 3 people, 5.56%
  6. Ammonia Increased: 3 people, 5.56%
  7. Hepatitis C: 3 people, 5.56%
  8. Diabetes: 2 people, 3.70%
  9. Stress And Anxiety: 2 people, 3.70%
  10. Ammonia Abnormal: 2 people, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Xifaxan and have Speech disorder?

- Check whether Speech disorder is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xifaxan:

Speech disorder treatments and more:

How severe was Speech disorder and when was it recovered:

Expand to all the drugs that have ingredients of rifaximin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xifaxan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Speech disorder:

Browse all the conditions that are associated with Speech disorder:


How the study uses the data?

The study uses data from the FDA. It is based on rifaximin (the active ingredients of Xifaxan) and Xifaxan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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