Xulane and Pain exacerbated - a phase IV clinical study of FDA data

Summary:

Pain exacerbated is reported as a side effect among people who take Xulane (ethinyl estradiol; norelgestromin), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Toradol, and have Endometriosis.

The phase IV clinical study analyzes which people have Pain exacerbated when taking Xulane. It is created by eHealthMe based on reports of 1,723 people who have side effects when taking Xulane from the FDA, and is updated regularly.

What is Xulane?

Xulane has active ingredients of ethinyl estradiol; norelgestromin. It is often used in birth control. eHealthMe is studying from 1,756 Xulane users. Check the latest studies of Xulane.

What is Pain exacerbated?

Pain exacerbated is found to be associated with 3,979 drugs and 3,033 conditions by eHealthMe. Check the latest studies of Pain exacerbated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

1,723 people reported to have side effects when taking Xulane.
Among them, 26 people (1.51%) have Pain exacerbated.

Among these 26 people:

How long have people been on Xulane when they have Pain exacerbated? *

What is the gender of people who have Pain exacerbated when taking Xulane? *

female: 100 %
male: 0.0 %

What is the age of people who have Pain exacerbated when taking Xulane? *

What are other drugs people take besides Xulane? *

What are other side effects people have besides Pain exacerbated? *

Nausea (feeling of having an urge to vomit): 6 people, 23.08%
Dizziness: 6 people, 23.08%
Nausea And Vomiting: 6 people, 23.08%
Fatigue (feeling of tiredness): 5 people, 19.23%
Drug Ineffective: 5 people, 19.23%
Headache (pain in head): 5 people, 19.23%
Thrombosis (formation of a blood clot inside a blood vessel): 5 people, 19.23%
Abdominal Pain Upper: 4 people, 15.38%
Insomnia (sleeplessness): 4 people, 15.38%
Facial Pain: 3 people, 11.54%

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 7.69%
Menstruation Irregular: 2 people, 7.69%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 2 people, 7.69%
Vaginal Odor: 1 person, 3.85%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 1 person, 3.85%
Premenstrual Syndrome: 1 person, 3.85%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 3.85%
Mittelschmerz (ovulation pain): 1 person, 3.85%
Fungal Infection: 1 person, 3.85%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Xulane and have Pain exacerbated?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xulane:

Xulane (1,756 reports)

Pain exacerbated treatments and more:

Pain exacerbated (1,595 reports)

How severe was Pain exacerbated and when was it recovered:

Pain exacerbated in Xulane

Expand to all the drugs that have ingredients of ethinyl estradiol; norelgestromin:

Pain exacerbated and drugs with ingredients of ethinyl estradiol; norelgestromin (320 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xulane:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pain exacerbated:

Pain exacerbated (3,979 drugs)

Browse all the conditions that are associated with Pain exacerbated:

Pain exacerbated (3,033 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norelgestromin (the active ingredients of Xulane) and Xulane (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.