Xylocaine and Injection site erythema - a phase IV clinical study of FDA data

Summary:

Injection site erythema is reported as a side effect among people who take Xylocaine (lidocaine hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Coumadin, and have Infection.

The phase IV clinical study analyzes which people have Injection site erythema when taking Xylocaine. It is created by eHealthMe based on reports of 5,700 people who have side effects when taking Xylocaine from the FDA, and is updated regularly.

What is Xylocaine?

Xylocaine has active ingredients of lidocaine hydrochloride. eHealthMe is studying from 5,716 Xylocaine users. Check the latest studies of Xylocaine.

What is Injection site erythema?

Injection site erythema (redness at injection site) is found to be associated with 1,458 drugs and 1,417 conditions by eHealthMe. Check the latest studies of Injection site erythema.

On Jul, 15, 2026

5,700 people reported to have side effects when taking Xylocaine.
Among them, 29 people (0.51%) have Injection site erythema.

Could Xylocaine cause Injection site erythema?

Among these 29 people:

How long have people been on Xylocaine when they have Injection site erythema? *

What is the gender of people who have Injection site erythema when taking Xylocaine? *

female: 60.87 %
male: 39.13 %

What is the age of people who have Injection site erythema when taking Xylocaine? *

What are other drugs people take besides Xylocaine? *

What are other side effects people have besides Injection site erythema? *

Malaise (a feeling of general discomfort or uneasiness): 6 people, 20.69%
Fever: 6 people, 20.69%
Hypersensitivity: 5 people, 17.24%
Injection Site Induration: 5 people, 17.24%
Injection Site Necrosis (death of body tissue at injection site): 4 people, 13.79%
Injection Site Pain: 4 people, 13.79%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 3 people, 10.34%
Fatigue (feeling of tiredness): 2 people, 6.90%
Rashes (redness): 2 people, 6.90%
Injection Site Oedema: 2 people, 6.90%

What are the existing conditions these people have? *

Infection: 4 people, 13.79%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.90%
Pain: 1 person, 3.45%
Osteoporosis (bones weak and more likely to break): 1 person, 3.45%
Local Anaesthesia: 1 person, 3.45%
High Blood Pressure: 1 person, 3.45%
Epidural Anaesthesia: 1 person, 3.45%
Depression: 1 person, 3.45%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 3.45%
Cardiac Disorder: 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Xylocaine and have Injection site erythema?

- Check whether Injection site erythema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xylocaine:

Xylocaine (5,716 reports)

Browse all side effects of Xylocaine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site erythema:

Injection site erythema (1,458 drugs)

Browse all the conditions that are associated with Injection site erythema:

Injection site erythema (1,417 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lidocaine hydrochloride (the active ingredients of Xylocaine) and Xylocaine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.