Xylocaine and Oedema - a phase IV clinical study of FDA data

Summary:

Oedema is reported as a side effect among people who take Xylocaine (lidocaine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Dilaudid, and have Nausea.

The phase IV clinical study analyzes which people have Oedema when taking Xylocaine. It is created by eHealthMe based on reports of 5,700 people who have side effects when taking Xylocaine from the FDA, and is updated regularly.

What is Xylocaine?

Xylocaine has active ingredients of lidocaine hydrochloride. eHealthMe is studying from 5,716 Xylocaine users. Check the latest studies of Xylocaine.

What is Oedema?

Oedema (fluid collection in tissue) is found to be associated with 2,182 drugs and 2,311 conditions by eHealthMe. Check the latest studies of Oedema.

On Jul, 20, 2026

5,700 people reported to have side effects when taking Xylocaine.
Among them, 77 people (1.35%) have Oedema.

Among these 77 people:

How long have people been on Xylocaine when they have Oedema? *

What is the gender of people who have Oedema when taking Xylocaine? *

female: 62.34 %
male: 37.66 %

What is the age of people who have Oedema when taking Xylocaine? *

What are other drugs people take besides Xylocaine? *

What are other side effects people have besides Oedema? *

Weight Decreased: 31 people, 40.26%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 29 people, 37.66%
Pneumonia: 29 people, 37.66%
Back Pain: 27 people, 35.06%
Pain: 21 people, 27.27%
General Physical Health Deterioration (weak health status): 20 people, 25.97%
Dyspnea (difficult or laboured breathing): 20 people, 25.97%
Stress And Anxiety: 19 people, 24.68%
Pleural Effusion (water on the lungs): 19 people, 24.68%
Hypoaesthesia (reduced sense of touch or sensation): 18 people, 23.38%

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 14 people, 18.18%
Multiple Myeloma (cancer of the plasma cells): 12 people, 15.58%
Oral Pain: 12 people, 15.58%
Depression: 12 people, 15.58%
Cough: 7 people, 9.09%
Immunodeficiency Disorders: 4 people, 5.19%
Local Anaesthesia: 4 people, 5.19%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 3 people, 3.90%
Constipation: 2 people, 2.60%
Lung Infection: 2 people, 2.60%

* Approximation only. Some reports may have incomplete information.

Do you take Xylocaine and have Oedema?

- Check whether Oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xylocaine:

Xylocaine (5,716 reports)

Oedema treatments and more:

Oedema (78,747 reports)

Browse all side effects of Xylocaine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oedema:

Oedema (2,182 drugs)

Browse all the conditions that are associated with Oedema:

Oedema (2,311 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lidocaine hydrochloride (the active ingredients of Xylocaine) and Xylocaine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.