Xyrem and Hyperchlorhydria - a phase IV clinical study of FDA data

Summary:

Hyperchlorhydria is reported as a side effect among people who take Xyrem (sodium oxybate), especially for people who are female, 30-39 old, have been taking the drug for 1 - 6 months also take Nuvigil, and have Drowsiness.

The phase IV clinical study analyzes which people have Hyperchlorhydria when taking Xyrem. It is created by eHealthMe based on reports of 81,139 people who have side effects when taking Xyrem from the FDA, and is updated regularly.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

What is Hyperchlorhydria?

Hyperchlorhydria (gastric acid levels are higher in stomach) is found to be associated with 390 drugs and 476 conditions by eHealthMe. Check the latest studies of Hyperchlorhydria.

On Jul, 16, 2026

81,139 people reported to have side effects when taking Xyrem.
Among them, 20 people (0.02%) have Hyperchlorhydria.

Among these 20 people:

How long have people been on Xyrem when they have Hyperchlorhydria? *

What is the gender of people who have Hyperchlorhydria when taking Xyrem? *

female: 84.21 %
male: 15.79 %

What is the age of people who have Hyperchlorhydria when taking Xyrem? *

What are other drugs people take besides Xyrem? *

What are other side effects people have besides Hyperchlorhydria? *

Feeling Abnormal: 11 people, 55.00%
Nausea (feeling of having an urge to vomit): 9 people, 45.00%
Malaise (a feeling of general discomfort or uneasiness): 7 people, 35.00%
Dysstasia (difficulty in standing): 6 people, 30.00%
Appetite - Increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 6 people, 30.00%
Gastric Disorder (disease of stomach): 5 people, 25.00%
Hyperhidrosis (abnormally increased sweating): 5 people, 25.00%
Dizziness: 5 people, 25.00%
Nausea And Vomiting: 5 people, 25.00%
Nervousness: 5 people, 25.00%

What are the existing conditions these people have? *

Drowsiness: 5 people, 25.00%
Weight Decreased: 4 people, 20.00%
High Blood Cholesterol: 4 people, 20.00%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 5.00%
Birth Control: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Xyrem and have Hyperchlorhydria?

- Check whether Hyperchlorhydria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xyrem:

Xyrem (81,487 reports)

Hyperchlorhydria treatments and more:

Hyperchlorhydria (52,226 reports)

Browse all side effects of Xyrem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperchlorhydria:

Hyperchlorhydria (390 drugs)

Browse all the conditions that are associated with Hyperchlorhydria:

Hyperchlorhydria (476 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sodium oxybate (the active ingredients of Xyrem) and Xyrem (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.