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Xyrem and Hypernatraemia - a phase IV clinical study of FDA data

Summary:

Hypernatraemia is reported as a side effect among people who take Xyrem (sodium oxybate), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Effexor, and have Drowsiness.

The phase IV clinical study analyzes which people have Hypernatraemia when taking Xyrem. It is created by eHealthMe based on reports of 81,139 people who have side effects when taking Xyrem from the FDA, and is updated regularly.

What is Xyrem?

Xyrem has active ingredients of sodium oxybate. It is often used in narcolepsy. eHealthMe is studying from 81,487 Xyrem users. Check the latest studies of Xyrem.

What is Hypernatraemia?

Hypernatraemia (an abnormally high plasma concentration of sodium ions) is found to be associated with 655 drugs and 805 conditions by eHealthMe. Check the latest studies of Hypernatraemia.

On Jul, 15, 2026

81,139 people reported to have side effects when taking Xyrem.
Among them, 13 people (0.02%) have Hypernatraemia.

Could Xyrem cause Hypernatraemia?

Among these 13 people:

How long have people been on Xyrem when they have Hypernatraemia? *

  • < 1 month: 33.33 %
  • 1 - 6 months: 33.33 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 33.33 %
  • 10+ years: 0.0 %

What is the gender of people who have Hypernatraemia when taking Xyrem? *

  • female: 66.67 %
  • male: 33.33 %

What is the age of people who have Hypernatraemia when taking Xyrem? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 11.11 %
  • 20-29: 11.11 %
  • 30-39: 11.11 %
  • 40-49: 44.44 %
  • 50-59: 11.11 %
  • 60+: 11.11 %

What are other drugs people take besides Xyrem? *

  1. Alcohol: 2 people, 15.38%
  2. Effexor: 2 people, 15.38%
  3. Xanax: 1 person, 7.69%
  4. Dynacin: 1 person, 7.69%
  5. Lamictal: 1 person, 7.69%
  6. Klor-Con: 1 person, 7.69%
  7. Hydroxyzine: 1 person, 7.69%
  8. Halcion: 1 person, 7.69%
  9. Gabapentin: 1 person, 7.69%
  10. Escitalopram: 1 person, 7.69%

What are other side effects people have besides Hypernatraemia? *

  1. Agitation (state of anxiety or nervous excitement): 5 people, 38.46%
  2. Suicide Attempt: 4 people, 30.77%
  3. Consciousness - Decreased: 3 people, 23.08%
  4. High Blood Pressure: 3 people, 23.08%
  5. Metabolic Alkalosis (too much bicarbonate in the blood): 3 people, 23.08%
  6. Pain: 3 people, 23.08%
  7. Arrhythmias (irregular heartbeat): 2 people, 15.38%
  8. Blood Creatine Phosphokinase Increased: 2 people, 15.38%
  9. Blood Creatinine Increased: 2 people, 15.38%
  10. Hypokalemia (low potassium): 2 people, 15.38%

What are the existing conditions these people have? *

  1. Insomnia (sleeplessness): 2 people, 15.38%
  2. Drowsiness: 2 people, 15.38%
  3. Stress And Anxiety: 1 person, 7.69%
  4. High Blood Pressure: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Xyrem and have Hypernatraemia?

- Check whether Hypernatraemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xyrem:

Hypernatraemia treatments and more:

How severe was Hypernatraemia and when was it recovered:

Expand to all the drugs that have ingredients of sodium oxybate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xyrem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypernatraemia:

Browse all the conditions that are associated with Hypernatraemia:

How the study uses the data?

The study uses data from the FDA. It is based on sodium oxybate (the active ingredients of Xyrem) and Xyrem (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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