Yaz and Angioedema - a phase IV clinical study of FDA data

Summary:

Angioedema is reported as a side effect among people who take Yaz (drospirenone; ethinyl estradiol), especially for people who are female, 30-39 old, have been taking the drug for 6 - 12 months also take Yasmin, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Angioedema when taking Yaz. It is created by eHealthMe based on reports of 39,984 people who have side effects when taking Yaz from the FDA, and is updated regularly.

What is Yaz?

Yaz has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 41,514 Yaz users. Check the latest studies of Yaz.

What is Angioedema?

Angioedema (rapid swelling of the dermis) is found to be associated with 1,199 drugs and 2,100 conditions by eHealthMe. Check the latest studies of Angioedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

39,984 people reported to have side effects when taking Yaz.
Among them, 17 people (0.04%) have Angioedema.

Among these 17 people:

How long have people been on Yaz when they have Angioedema? *

What is the gender of people who have Angioedema when taking Yaz? *

female: 88.24 %
male: 11.76 %

What is the age of people who have Angioedema when taking Yaz? *

What are other drugs people take besides Yaz? *

What are other side effects people have besides Angioedema? *

Dyspnea (difficult or laboured breathing): 4 people, 23.53%
Itching: 4 people, 23.53%
Swelling Face: 3 people, 17.65%
Cholecystitis Chronic (long lasting infection of gallbladder): 3 people, 17.65%
Rashes (redness): 3 people, 17.65%
Pain: 3 people, 17.65%
Urticaria (rash of round, red welts on the skin that itch intensely): 2 people, 11.76%
Nausea And Vomiting: 2 people, 11.76%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 11.76%
Eye Pruritus (eye itching): 2 people, 11.76%

What are the existing conditions these people have? *

Premenstrual Syndrome: 3 people, 17.65%
Migraine (headache): 3 people, 17.65%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 17.65%
Acne (skin problems that cause pimples): 2 people, 11.76%
Hereditary Angioedema (recurrent episodes of severe swelling): 1 person, 5.88%
Allergic Rhinitis: 1 person, 5.88%
Depression: 1 person, 5.88%
Dyspnea (difficult or laboured breathing): 1 person, 5.88%
Gallbladder Disorder: 1 person, 5.88%
Gastric Ulcer (stomach ulcer): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Yaz and have Angioedema?

- Check whether Angioedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Yaz:

Yaz (41,514 reports)

Angioedema treatments and more:

Angioedema (44,989 reports)

How severe was Angioedema and when was it recovered:

Angioedema in Yaz

Expand to all the drugs that have ingredients of drospirenone; ethinyl estradiol:

Angioedema and drugs with ingredients of drospirenone; ethinyl estradiol (50 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Yaz:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Angioedema:

Angioedema (1,199 drugs)

Browse all the conditions that are associated with Angioedema:

Angioedema (2,100 conditions)

Related publications that referenced our studies

Banaga, Y., Mohmmed, K., Mustafa, H., & Barrett, J, "Angioedema 2 months after Administration of Rivaroxaban (Xarelto)", J Clin Case Rep, 2014 Jan .
Banaga, Y., Mohmmed, K., Mustafa, H., & Barrett, J, "Angioedema 2 months after Administration of Rivaroxaban (Xarelto)", J Clin Case Rep, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on drospirenone; ethinyl estradiol (the active ingredients of Yaz) and Yaz (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.