Zantac 75 and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Zantac 75 (ranitidine hydrochloride), especially for people who are male, 50-59 old, have been taking the drug for 10+ years also take Prilosec, and have Pain.

The phase IV clinical study analyzes which people have Depression when taking Zantac 75. It is created by eHealthMe based on reports of 3,615 people who have side effects when taking Zantac 75 from the FDA, and is updated regularly.

What is Zantac 75?

Zantac 75 has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 3,796 Zantac 75 users. Check the latest studies of Zantac 75.

What is Depression?

Depression is found to be associated with 3,168 drugs and 4,126 conditions by eHealthMe. Check the latest studies of Depression.

On Jul, 24, 2026

3,615 people reported to have side effects when taking Zantac 75.
Among them, 48 people (1.33%) have Depression.

Among these 48 people:

How long have people been on Zantac 75 when they have Depression? *

What is the gender of people who have Depression when taking Zantac 75? *

female: 41.94 %
male: 58.06 %

What is the age of people who have Depression when taking Zantac 75? *

What are other drugs people take besides Zantac 75? *

What are other side effects people have besides Depression? *

Chronic Kidney Disease: 25 people, 52.08%
Stress And Anxiety: 18 people, 37.50%
Acute Kidney Failure: 12 people, 25.00%
Mood Swings (an extreme or rapid change in mood): 6 people, 12.50%
General Physical Health Deterioration (weak health status): 6 people, 12.50%
Liver Disorder (liver diseases): 6 people, 12.50%
Malaise (a feeling of general discomfort or uneasiness): 5 people, 10.42%
Suicidal Ideation: 5 people, 10.42%
Sleep Disorder: 4 people, 8.33%
Neoplasm Malignant (cancer tumour): 4 people, 8.33%

What are the existing conditions these people have? *

Pain: 20 people, 41.67%
Diabetes: 8 people, 16.67%
Dyspnea (difficult or laboured breathing): 6 people, 12.50%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 6 people, 12.50%
High Blood Pressure: 6 people, 12.50%
Infection: 6 people, 12.50%
Oedema (fluid collection in tissue): 6 people, 12.50%
Blood Pressure Abnormal: 5 people, 10.42%
Gastric Infection (infection of stomach): 4 people, 8.33%
Nausea (feeling of having an urge to vomit): 4 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Zantac 75 and have Depression?

- Check whether Depression is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zantac 75:

Zantac 75 (3,796 reports)

Depression treatments and more:

Depression (652,144 reports)

Browse all side effects of Zantac 75:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,168 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,126 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on ranitidine hydrochloride (the active ingredients of Zantac 75) and Zantac 75 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.