Zantac and Hypernatraemia - a phase IV clinical study of FDA data

Summary:

Hypernatraemia is reported as a side effect among people who take Zantac (ranitidine hydrochloride), especially for people who are male, 60+ old, also take Lasix, and have High blood pressure.

The phase IV clinical study analyzes which people have Hypernatraemia when taking Zantac. It is created by eHealthMe based on reports of 432,014 people who have side effects when taking Zantac from the FDA, and is updated regularly.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

What is Hypernatraemia?

Hypernatraemia (an abnormally high plasma concentration of sodium ions) is found to be associated with 655 drugs and 805 conditions by eHealthMe. Check the latest studies of Hypernatraemia.

On Jul, 14, 2026

432,014 people reported to have side effects when taking Zantac.
Among them, 35 people (0.01%) have Hypernatraemia.

Among these 35 people:

What is the gender of people who have Hypernatraemia when taking Zantac? *

female: 40 %
male: 60 %

What is the age of people who have Hypernatraemia when taking Zantac? *

What are other drugs people take besides Zantac? *

What are other side effects people have besides Hypernatraemia? *

Hypotension (abnormally low blood pressure): 9 people, 25.71%
Blood Creatinine Increased: 8 people, 22.86%
Dehydration (dryness resulting from the removal of water): 7 people, 20.00%
Anaemia (lack of blood): 6 people, 17.14%
Urinary Tract Infection: 6 people, 17.14%
Hyperkalemia (damage to or disease of the kidney): 6 people, 17.14%
Blood Urea Increased: 6 people, 17.14%
Haemoglobin Decreased: 6 people, 17.14%
Fever: 6 people, 17.14%
Bone Marrow Failure: 5 people, 14.29%

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 17.14%
Cardiac Failure: 4 people, 11.43%
Hyperglycemia (high blood sugar): 4 people, 11.43%
Pain: 3 people, 8.57%
Oedema (fluid collection in tissue): 3 people, 8.57%
Mantle Cell Lymphoma Stage Iv (cancer of lymphocytes, a type of white blood cell, spreads to other part of body): 3 people, 8.57%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 3 people, 8.57%
Constipation: 3 people, 8.57%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 3 people, 8.57%
Hepatitis C: 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

Do you take Zantac and have Hypernatraemia?

- Check whether Hypernatraemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zantac:

Zantac (434,161 reports)

Hypernatraemia treatments and more:

Hypernatraemia (6,339 reports)

Browse all side effects of Zantac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypernatraemia:

Hypernatraemia (655 drugs)

Browse all the conditions that are associated with Hypernatraemia:

Hypernatraemia (805 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ranitidine hydrochloride (the active ingredients of Zantac) and Zantac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.