Zantac and Subcutaneous emphysema - a phase IV clinical study of FDA data

Summary:

Subcutaneous emphysema is reported as a side effect among people who take Zantac (ranitidine hydrochloride), especially for people who are male, 60+ old, also take Oxycontin, and have Breast cancer.

The phase IV clinical study analyzes which people have Subcutaneous emphysema when taking Zantac. It is created by eHealthMe based on reports of 432,014 people who have side effects when taking Zantac from the FDA, and is updated regularly.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

What is Subcutaneous emphysema?

Subcutaneous emphysema (smooth bulging of the skin) is found to be associated with 169 drugs and 526 conditions by eHealthMe. Check the latest studies of Subcutaneous emphysema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

432,014 people reported to have side effects when taking Zantac.
Among them, 27 people (0.01%) have Subcutaneous emphysema.

Could Zantac cause Subcutaneous emphysema?

Among these 27 people:

What is the gender of people who have Subcutaneous emphysema when taking Zantac? *

female: 29.63 %
male: 70.37 %

What is the age of people who have Subcutaneous emphysema when taking Zantac? *

What are other drugs people take besides Zantac? *

What are other side effects people have besides Subcutaneous emphysema? *

Nausea (feeling of having an urge to vomit): 22 people, 81.48%
Nausea And Vomiting: 21 people, 77.78%
Dental Caries: 21 people, 77.78%
Lung Disorder (lung disease): 21 people, 77.78%
High Blood Pressure: 21 people, 77.78%
Bone Disorder: 21 people, 77.78%
Dyspnea (difficult or laboured breathing): 21 people, 77.78%
Pain In Jaw: 21 people, 77.78%
Pneumonia: 21 people, 77.78%
Asthma: 21 people, 77.78%

What are the existing conditions these people have? *

Pain: 5 people, 18.52%
Metastases To Bone (cancer spreads to bone): 5 people, 18.52%
Breast Cancer: 5 people, 18.52%
Multiple Myeloma (cancer of the plasma cells): 2 people, 7.41%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 3.70%
Heparin-Induced Thrombocytopenia: 1 person, 3.70%
Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Zantac and have Subcutaneous emphysema?

- Check whether Subcutaneous emphysema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zantac:

Zantac (434,161 reports)

Browse all side effects of Zantac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Subcutaneous emphysema:

Subcutaneous emphysema (169 drugs)

Browse all the conditions that are associated with Subcutaneous emphysema:

Subcutaneous emphysema (526 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ranitidine hydrochloride (the active ingredients of Zantac) and Zantac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.