Zantac and Tonic convulsion - a phase IV clinical study of FDA data

Summary:

Tonic convulsion is reported as a side effect among people who take Zantac (ranitidine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Keppra, and have Epilepsy.

The phase IV clinical study analyzes which people have Tonic convulsion when taking Zantac. It is created by eHealthMe based on reports of 432,014 people who have side effects when taking Zantac from the FDA, and is updated regularly.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

What is Tonic convulsion?

Tonic convulsion (the person will quickly lose consciousness and the skeletal muscles will suddenly tense, often causing the extremities to be pulled towards the body or rigidly pushed away from it) is found to be associated with 160 drugs and 384 conditions by eHealthMe. Check the latest studies of Tonic convulsion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

432,014 people reported to have side effects when taking Zantac.
Among them, 11 people (0.0%) have Tonic convulsion.

Among these 11 people:

How long have people been on Zantac when they have Tonic convulsion? *

What is the gender of people who have Tonic convulsion when taking Zantac? *

female: 63.64 %
male: 36.36 %

What is the age of people who have Tonic convulsion when taking Zantac? *

What are other drugs people take besides Zantac? *

What are other side effects people have besides Tonic convulsion? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 36.36%
Death: 3 people, 27.27%
Drug Ineffective: 3 people, 27.27%
Loss Of Consciousness: 2 people, 18.18%
Fever: 1 person, 9.09%
Altered State Of Consciousness (altered state of mind): 1 person, 9.09%
Cardiac Arrest: 1 person, 9.09%
Depressed Level Of Consciousness: 1 person, 9.09%
Dyspnea (difficult or laboured breathing): 1 person, 9.09%
Ventricular Extrasystoles (premature cardiac contraction): 1 person, 9.09%

What are the existing conditions these people have? *

Infantile Spasms: 4 people, 36.36%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 4 people, 36.36%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 18.18%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 1 person, 9.09%
Salivary Hypersecretion (excess saliva secretion): 1 person, 9.09%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%
Reflux Gastritis (a condition in which the lining of a person's stomach becomes inflamed as a result of exposure to bile): 1 person, 9.09%
Pain: 1 person, 9.09%
Ovarian Cancer (cancer of ovary): 1 person, 9.09%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Zantac and have Tonic convulsion?

- Check whether Tonic convulsion is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zantac:

Zantac (434,161 reports)

Browse all side effects of Zantac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tonic convulsion:

Tonic convulsion (160 drugs)

Browse all the conditions that are associated with Tonic convulsion:

Tonic convulsion (384 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ranitidine hydrochloride (the active ingredients of Zantac) and Zantac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.