Zestoretic and Hepatic failure - a phase IV clinical study of FDA data

Summary:

Hepatic failure is reported as a side effect among people who take Zestoretic (hydrochlorothiazide; lisinopril), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Lasix, and have Osteoporosis.

The phase IV clinical study analyzes which people have Hepatic failure when taking Zestoretic. It is created by eHealthMe based on reports of 4,193 people who have side effects when taking Zestoretic from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Hepatic failure?

Hepatic failure (liver failure) is found to be associated with 1,541 drugs and 1,892 conditions by eHealthMe. Check the latest studies of Hepatic failure.

On Jul, 12, 2026

4,193 people reported to have side effects when taking Zestoretic.
Among them, 25 people (0.6%) have Hepatic failure.

Among these 25 people:

How long have people been on Zestoretic when they have Hepatic failure? *

What is the gender of people who have Hepatic failure when taking Zestoretic? *

female: 68 %
male: 32 %

What is the age of people who have Hepatic failure when taking Zestoretic? *

What are other drugs people take besides Zestoretic? *

What are other side effects people have besides Hepatic failure? *

Ascites (accumulation of fluid in the abdominal cavity): 9 people, 36.00%
Weakness: 8 people, 32.00%
Confusional State: 8 people, 32.00%
Hypotension (abnormally low blood pressure): 8 people, 32.00%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 8 people, 32.00%
Bleeding Disorders: 7 people, 28.00%
Acute Kidney Failure: 7 people, 28.00%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 7 people, 28.00%
Cardiac Failure Congestive: 7 people, 28.00%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 7 people, 28.00%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 3 people, 12.00%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 2 people, 8.00%
Breast Cancer: 2 people, 8.00%
Asthma: 2 people, 8.00%
Neck Pain: 1 person, 4.00%
Hypersensitivity: 1 person, 4.00%
Hepatocellular Carcinoma (liver cancer): 1 person, 4.00%
Diabetes: 1 person, 4.00%
Back Pain: 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Zestoretic and have Hepatic failure?

- Check whether Hepatic failure is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zestoretic:

Zestoretic (4,342 reports)

Hepatic failure treatments and more:

Hepatic failure (44,058 reports)

How severe was Hepatic failure and when was it recovered:

Hepatic failure in Zestoretic

Expand to all the drugs that have ingredients of hydrochlorothiazide; lisinopril:

Hepatic failure and drugs with ingredients of hydrochlorothiazide; lisinopril

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zestoretic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic failure:

Hepatic failure (1,541 drugs)

Browse all the conditions that are associated with Hepatic failure:

Hepatic failure (1,892 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; lisinopril (the active ingredients of Zestoretic) and Zestoretic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.