Nucynta and Xarelto drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nucynta (tapentadol hydrochloride) and Xarelto (rivaroxaban). Common drug interactions include dehydration among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Nucynta and Xarelto. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

What is Xarelto?

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 212,377 Xarelto users. Check the latest studies of Xarelto.

On Jul, 12, 2026

77 people who take Nucynta and Xarelto together, and have interactions are studied.

What are the common drug interactions of Nucynta and Xarelto, by gender? *:

female:

Dehydration (dryness resulting from the removal of water)
Depression
Disease progression
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)
Erythema (redness of the skin)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hospitalisation

male:

Fall
Renal haematoma (blood collection in kidney)
Dry mouth
Dysgeusia (disorder of the sense of taste)
Flushing (the warm, red condition of human skin)
Gait disturbance
Memory impairment
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Mydriasis (a dilation of the pupil)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Nucynta and Xarelto, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pulmonary thrombosis (scarring in the lungs)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Skin tightness
Swelling
Thrombosis (formation of a blood clot inside a blood vessel)
Complication of device insertion
Disturbance in attention
Drug ineffective
Joint swelling
Neuralgia (pain in one or more nerves)

40-49:

Peripheral swelling
Abnormal loss of weight
Initial insomnia (feeling of inadequate or poor-quality sleep)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Diarrhoea
Epistaxis (bleed from the nose)
Haemorrhage (bleeding)
Nausea (feeling of having an urge to vomit)
Rectal haemorrhage (bleeding from anus)
Vaginal haemorrhage (vaginal bleeding)

50-59:

Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Pulmonary alveolar haemorrhage (acute bleeding)
Pulmonary haemorrhage (acute bleeding from the lung)
Respiratory failure (inadequate gas exchange by the respiratory system)
Chronic kidney disease
Epistaxis (bleed from the nose)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Rash pruritic (redness with itching)
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Anaemia (lack of blood)

60+:

Fall
Renal haematoma (blood collection in kidney)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Activities of daily living impaired
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Flushing (the warm, red condition of human skin)
Memory impairment
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 14.29%
Cardiac Disorder: 8 people, 10.39%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 7 people, 9.09%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 7 people, 9.09%
Back Pain: 6 people, 7.79%
Sleep Disorder: 6 people, 7.79%
High Blood Pressure: 6 people, 7.79%
High Blood Cholesterol: 5 people, 6.49%
Thrombosis (formation of a blood clot inside a blood vessel): 5 people, 6.49%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 6.49%

* Approximation only. Some reports may have incomplete information.

Do you take Nucynta and Xarelto?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously