Zestril and Irritability - a phase IV clinical study of FDA data

Summary:

Irritability is reported as a side effect among people who take Zestril (lisinopril), especially for people who are male, 60+ old, also take Coumadin, and have Pain.

The phase IV clinical study analyzes which people have Irritability when taking Zestril. It is created by eHealthMe based on reports of 21,786 people who have side effects when taking Zestril from the FDA, and is updated regularly.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

What is Irritability?

Irritability is found to be associated with 1,700 drugs and 2,458 conditions by eHealthMe. Check the latest studies of Irritability.

On Jul, 16, 2026

21,786 people reported to have side effects when taking Zestril.
Among them, 66 people (0.3%) have Irritability.

Among these 66 people:

What is the gender of people who have Irritability when taking Zestril? *

female: 47.69 %
male: 52.31 %

What is the age of people who have Irritability when taking Zestril? *

What are other drugs people take besides Zestril? *

What are other side effects people have besides Irritability? *

Stress And Anxiety: 35 people, 53.03%
Depression: 28 people, 42.42%
Insomnia (sleeplessness): 28 people, 42.42%
Headache (pain in head): 25 people, 37.88%
Hypoaesthesia (reduced sense of touch or sensation): 24 people, 36.36%
Confusional State: 21 people, 31.82%
Nausea (feeling of having an urge to vomit): 20 people, 30.30%
Memory Loss: 19 people, 28.79%
Tremor (trembling or shaking movements in one or more parts of your body): 18 people, 27.27%
Fatigue (feeling of tiredness): 18 people, 27.27%

What are the existing conditions these people have? *

Pain: 18 people, 27.27%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 7.58%
High Blood Cholesterol: 5 people, 7.58%
Stress And Anxiety: 5 people, 7.58%
Insomnia (sleeplessness): 3 people, 4.55%
Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 4.55%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 3.03%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 3.03%
Nausea (feeling of having an urge to vomit): 2 people, 3.03%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Zestril and have Irritability?

- Check whether Irritability is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zestril:

Zestril (22,273 reports)

Irritability treatments and more:

Irritability (71,614 reports)

Browse all side effects of Zestril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Irritability:

Irritability (1,700 drugs)

Browse all the conditions that are associated with Irritability:

Irritability (2,458 conditions)

Related publications that referenced our studies

Dobrosavljevi? Vukojevi? D, Stojkovi? Filipovi? J, Sjerobabin M, Vukovi? J, Vesi? S, "Lisinopril-induced pemphigus foliaceus in a patient with diabetes mellitus and Kaposi-Juliusberg varicelliform eruption", Serbian Journal of Dermatology and Venerology, 2012 Dec .
Dobrosavljevi? Vukojevi? D, Stojkovi? Filipovi? J, Sjerobabin M, Vukovi? J, Vesi? S, "Lisinopril-induced pemphigus foliaceus in a patient with diabetes mellitus and Kaposi-Juliusberg varicelliform eruption", Serbian Journal of Dermatology and Venerology, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on lisinopril (the active ingredients of Zestril) and Zestril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.