Zestril and Necrosis - a phase IV clinical study of FDA data

Summary:

Necrosis is reported as a side effect among people who take Zestril (lisinopril), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Bactrim, and have Systemic sclerosis (scleroderma).

The phase IV clinical study analyzes which people have Necrosis when taking Zestril. It is created by eHealthMe based on reports of 21,786 people who have side effects when taking Zestril from the FDA, and is updated regularly.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

What is Necrosis?

Necrosis (the death of body tissue) is found to be associated with 748 drugs and 970 conditions by eHealthMe. Check the latest studies of Necrosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

21,786 people reported to have side effects when taking Zestril.
Among them, 30 people (0.14%) have Necrosis.

Among these 30 people:

How long have people been on Zestril when they have Necrosis? *

What is the gender of people who have Necrosis when taking Zestril? *

female: 56.67 %
male: 43.33 %

What is the age of people who have Necrosis when taking Zestril? *

What are other drugs people take besides Zestril? *

What are other side effects people have besides Necrosis? *

Blood Creatinine Increased: 8 people, 26.67%
Acute Kidney Failure: 7 people, 23.33%
Infection: 6 people, 20.00%
Multi-Organ Failure (multisystem organ failure): 5 people, 16.67%
Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 4 people, 13.33%
Glomerular Filtration Rate Decreased: 4 people, 13.33%
General Physical Health Deterioration (weak health status): 4 people, 13.33%
Gastrointestinal Ischaemia (less blood supply to gastrointestinal tract): 4 people, 13.33%
Thrombocytopenia (decrease of platelets in blood): 4 people, 13.33%
Aseptic Necrosis (the death of bone tissue due to a lack of blood supply): 4 people, 13.33%

What are the existing conditions these people have? *

Diabetes: 3 people, 10.00%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 3 people, 10.00%
Arterial Disorder: 2 people, 6.67%
Sleep Disorder: 2 people, 6.67%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 6.67%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 6.67%
Depression: 2 people, 6.67%
Type 2 Diabetes: 2 people, 6.67%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 6.67%
Dyslipidaemia (abnormal amount of lipids): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Zestril and have Necrosis?

- Check whether Necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zestril:

Zestril (22,273 reports)

Necrosis treatments and more:

Necrosis (8,274 reports)

Browse all side effects of Zestril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Necrosis:

Necrosis (748 drugs)

Browse all the conditions that are associated with Necrosis:

Necrosis (970 conditions)

Related publications that referenced our studies

Dobrosavljevi? Vukojevi? D, Stojkovi? Filipovi? J, Sjerobabin M, Vukovi? J, Vesi? S, "Lisinopril-induced pemphigus foliaceus in a patient with diabetes mellitus and Kaposi-Juliusberg varicelliform eruption", Serbian Journal of Dermatology and Venerology, 2012 Dec .
Dobrosavljevi? Vukojevi? D, Stojkovi? Filipovi? J, Sjerobabin M, Vukovi? J, Vesi? S, "Lisinopril-induced pemphigus foliaceus in a patient with diabetes mellitus and Kaposi-Juliusberg varicelliform eruption", Serbian Journal of Dermatology and Venerology, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on lisinopril (the active ingredients of Zestril) and Zestril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.