Zestril and Optic neuritis - a phase IV clinical study of FDA data

Summary:

Optic neuritis is reported as a side effect among people who take Zestril (lisinopril), especially for people who are male, 60+ old, also take Synthroid, and have Depression.

The phase IV clinical study analyzes which people have Optic neuritis when taking Zestril. It is created by eHealthMe based on reports of 21,786 people who have side effects when taking Zestril from the FDA, and is updated regularly.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

What is Optic neuritis?

Optic neuritis (optic nerve inflammation) is found to be associated with 641 drugs and 814 conditions by eHealthMe. Check the latest studies of Optic neuritis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

21,786 people reported to have side effects when taking Zestril.
Among them, 13 people (0.06%) have Optic neuritis.

Among these 13 people:

What is the gender of people who have Optic neuritis when taking Zestril? *

female: 38.46 %
male: 61.54 %

What is the age of people who have Optic neuritis when taking Zestril? *

What are other drugs people take besides Zestril? *

What are other side effects people have besides Optic neuritis? *

Fall: 4 people, 30.77%
Hyperhidrosis (abnormally increased sweating): 3 people, 23.08%
Dry Mouth: 3 people, 23.08%
Depression: 3 people, 23.08%
Nausea (feeling of having an urge to vomit): 3 people, 23.08%
Diarrhea: 3 people, 23.08%
Burning Sensation: 3 people, 23.08%
Hypoaesthesia (reduced sense of touch or sensation): 2 people, 15.38%
Stress And Anxiety: 2 people, 15.38%
Pain In Extremity: 2 people, 15.38%

What are the existing conditions these people have? *

Depression: 3 people, 23.08%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 15.38%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 7.69%
Nuclear Magnetic Resonance Imaging Abdominal: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Zestril and have Optic neuritis?

- Check whether Optic neuritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zestril:

Zestril (22,273 reports)

Optic neuritis treatments and more:

Optic neuritis (11,743 reports)

Browse all side effects of Zestril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Optic neuritis:

Optic neuritis (641 drugs)

Browse all the conditions that are associated with Optic neuritis:

Optic neuritis (814 conditions)

Related publications that referenced our studies

Dobrosavljevi? Vukojevi? D, Stojkovi? Filipovi? J, Sjerobabin M, Vukovi? J, Vesi? S, "Lisinopril-induced pemphigus foliaceus in a patient with diabetes mellitus and Kaposi-Juliusberg varicelliform eruption", Serbian Journal of Dermatology and Venerology, 2012 Dec .
Dobrosavljevi? Vukojevi? D, Stojkovi? Filipovi? J, Sjerobabin M, Vukovi? J, Vesi? S, "Lisinopril-induced pemphigus foliaceus in a patient with diabetes mellitus and Kaposi-Juliusberg varicelliform eruption", Serbian Journal of Dermatology and Venerology, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on lisinopril (the active ingredients of Zestril) and Zestril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.