Ziac and Muscle strain - a phase IV clinical study of FDA data

Summary:

Muscle strain is reported as a side effect among people who take Ziac (bisoprolol fumarate; hydrochlorothiazide), especially for people who are female, 60+ old, also take Protonix, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Muscle strain when taking Ziac. It is created by eHealthMe based on reports of 4,207 people who have side effects when taking Ziac from the FDA, and is updated regularly.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

What is Muscle strain?

Muscle strain (an injury to a muscle in which the muscle fibres tear) is found to be associated with 922 drugs and 828 conditions by eHealthMe. Check the latest studies of Muscle strain.

On Jul, 31, 2026

4,207 people reported to have side effects when taking Ziac.
Among them, 12 people (0.29%) have Muscle strain.

Among these 12 people:

What is the gender of people who have Muscle strain when taking Ziac? *

female: 100 %
male: 0.0 %

What is the age of people who have Muscle strain when taking Ziac? *

What are other drugs people take besides Ziac? *

What are other side effects people have besides Muscle strain? *

Back Pain: 9 people, 75.00%
Oedema Peripheral (superficial swelling): 7 people, 58.33%
Rickets (softening of bones): 6 people, 50.00%
Rib Fracture: 6 people, 50.00%
Pubis Fracture: 6 people, 50.00%
Nausea (feeling of having an urge to vomit): 6 people, 50.00%
Increased Tendency To Bruise (increased tendency to injure the underlying soft tissue or bone): 6 people, 50.00%
Pneumonia: 6 people, 50.00%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 6 people, 50.00%
Calcium Deficiency (lack of calcium): 6 people, 50.00%

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 6 people, 50.00%
Seasonal Allergy (allergic condition due to certain season): 6 people, 50.00%
Osteoporosis (bones weak and more likely to break): 6 people, 50.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 50.00%
High Blood Cholesterol: 4 people, 33.33%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 25.00%
Multiple Myeloma (cancer of the plasma cells): 1 person, 8.33%
Breast Cancer: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Ziac and have Muscle strain?

- Check whether Muscle strain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ziac:

Ziac (4,451 reports)

Muscle strain treatments and more:

Muscle strain (12,853 reports)

How severe was Muscle strain and when was it recovered:

Muscle strain in Ziac

Expand to all the drugs that have ingredients of bisoprolol fumarate; hydrochlorothiazide:

Muscle strain and drugs with ingredients of bisoprolol fumarate; hydrochlorothiazide

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ziac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle strain:

Muscle strain (922 drugs)

Browse all the conditions that are associated with Muscle strain:

Muscle strain (828 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bisoprolol fumarate; hydrochlorothiazide (the active ingredients of Ziac) and Ziac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.