Zide and Accidental death - a phase IV clinical study of FDA data

Summary:

Accidental death is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Lisinopril, and have Back pain.

The study is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Jul, 08, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 12 people (0.01%) died.

Among these 12 people:

How long have people been on Zide when they died? *

What is the gender of people who died when taking Zide? *

female: 16.67 %
male: 83.33 %

What is the age of people who died when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have before they died? *

Drug Toxicity: 7 people, 58.33%
Sleep Apnea Syndrome: 4 people, 33.33%
Drug Abuse: 4 people, 33.33%
Unresponsive To Stimuli: 3 people, 25.00%
Breathing - Slowed Or Stopped: 3 people, 25.00%
Hydrocephalus (water on the brain): 3 people, 25.00%
Drug Level Above Therapeutic: 3 people, 25.00%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 25.00%
Cerebral Ischaemia (insufficient blood flow to the brain to meet metabolic demand): 3 people, 25.00%
Blood Glucose Increased: 3 people, 25.00%

What are the existing conditions these people have? *

Stress And Anxiety: 3 people, 25.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 25.00%
Hepatitis C: 3 people, 25.00%
Back Pain: 3 people, 25.00%
Ill-Defined Disorder: 2 people, 16.67%
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly): 1 person, 8.33%
Pain: 1 person, 8.33%
Joint Pain: 1 person, 8.33%
Breakthrough Pain: 1 person, 8.33%
Asthma: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Expand to all the drugs that have ingredients of hydrochlorothiazide:

Accidental death and drugs with ingredients of hydrochlorothiazide

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Accidental death:

Accidental death (147 drugs)

Browse all the conditions that are associated with Accidental death:

Accidental death (170 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.