Zide and Adverse reaction - a phase IV clinical study of FDA data

Summary:

Adverse reaction is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Metformin, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Adverse reaction when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Adverse reaction?

Adverse reaction is found to be associated with 654 drugs and 658 conditions by eHealthMe. Check the latest studies of Adverse reaction.

On Jul, 19, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 64 people (0.04%) have Adverse reaction.

Among these 64 people:

How long have people been on Zide when they have Adverse reaction? *

What is the gender of people who have Adverse reaction when taking Zide? *

female: 64.52 %
male: 35.48 %

What is the age of people who have Adverse reaction when taking Zide? *

What are other drugs people take besides Zide? *

Lisinopril: 7 people, 10.94%
Vitamin D3: 7 people, 10.94%
Metformin: 7 people, 10.94%
Albuterol: 6 people, 9.38%
Duloxetine Hydrochloride: 6 people, 9.38%
Amlodipine: 6 people, 9.38%
Revlimid: 6 people, 9.38%
Omeprazole: 5 people, 7.81%
Fish Oil: 5 people, 7.81%
Rosuvastatin Calcium: 5 people, 7.81%

What are other side effects people have besides Adverse reaction? *

Fatigue (feeling of tiredness): 12 people, 18.75%
Nausea (feeling of having an urge to vomit): 12 people, 18.75%
Weakness: 11 people, 17.19%
Hypotension (abnormally low blood pressure): 10 people, 15.62%
Pain: 9 people, 14.06%
Diarrhea: 9 people, 14.06%
Malaise (a feeling of general discomfort or uneasiness): 8 people, 12.50%
Nausea And Vomiting: 8 people, 12.50%
Sleep Disorder: 8 people, 12.50%
Balance Disorder: 7 people, 10.94%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 7 people, 10.94%
Immunodeficiency Common Variable: 5 people, 7.81%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 7.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.81%
High Blood Cholesterol: 3 people, 4.69%
Iga Nephropathy (kidney disease- condition prevents the kidneys from filtering waste): 3 people, 4.69%
Diabetes: 3 people, 4.69%
Low Density Lipoprotein Increased (cholesterol increased in blood): 3 people, 4.69%
Nausea (feeling of having an urge to vomit): 3 people, 4.69%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 4.69%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Adverse reaction?

- Check whether Adverse reaction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Adverse reaction treatments and more:

Adverse reaction (13,279 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Adverse reaction:

Adverse reaction (654 drugs)

Browse all the conditions that are associated with Adverse reaction:

Adverse reaction (658 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.