Zide and Hypogeusia - a phase IV clinical study of FDA data

Summary:

Hypogeusia is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are female, 60+ old, also take Levothyroxine Sodium, and have Idiopathic thrombocytopenic purpura.

The phase IV clinical study analyzes which people have Hypogeusia when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Hypogeusia?

Hypogeusia (reduced ability to taste things (to taste sweet, sour, bitter, or salty substances)) is found to be associated with 262 drugs and 388 conditions by eHealthMe. Check the latest studies of Hypogeusia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 32 people (0.02%) have Hypogeusia.

Among these 32 people:

What is the gender of people who have Hypogeusia when taking Zide? *

female: 84.38 %
male: 15.62 %

What is the age of people who have Hypogeusia when taking Zide? *

What are other drugs people take besides Zide? *

Levothyroxine Sodium: 8 people, 25.00%
Metformin: 5 people, 15.62%
Mirabegron: 5 people, 15.62%
Kesimpta: 5 people, 15.62%
Oxycodone: 3 people, 9.38%
Ocrevus: 3 people, 9.38%
Nplate: 3 people, 9.38%
Glyburide And Metformin Hydrochloride: 3 people, 9.38%
Black Cumin: 3 people, 9.38%
Zofran: 2 people, 6.25%

What are other side effects people have besides Hypogeusia? *

Fatigue (feeling of tiredness): 14 people, 43.75%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 9 people, 28.12%
Weakness: 8 people, 25.00%
Swallowing Difficulty: 7 people, 21.88%
Taste - Impaired: 6 people, 18.75%
Back Pain: 6 people, 18.75%
Neck Pain: 5 people, 15.62%
Constipation: 5 people, 15.62%
Indigestion: 5 people, 15.62%
Lip Disorder (disease of lip): 5 people, 15.62%

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 9.38%
Renal Cell Carcinoma (a kidney cancer): 3 people, 9.38%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 3 people, 9.38%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 6.25%
Prostate Cancer: 2 people, 6.25%
Multiple Myeloma (cancer of the plasma cells): 2 people, 6.25%
Colon Cancer: 2 people, 6.25%
Kidney Stones: 2 people, 6.25%
Stable Angina (a constant chest pain): 1 person, 3.12%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Hypogeusia?

- Check whether Hypogeusia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Hypogeusia treatments and more:

Hypogeusia (2,199 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypogeusia:

Hypogeusia (262 drugs)

Browse all the conditions that are associated with Hypogeusia:

Hypogeusia (388 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.