Zide and International normalised ratio abnormal - a phase IV clinical study of FDA data

Summary:

International normalised ratio abnormal is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Coumadin, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have International normalised ratio abnormal when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is International normalised ratio abnormal?

International normalised ratio abnormal is found to be associated with 329 drugs and 472 conditions by eHealthMe. Check the latest studies of International normalised ratio abnormal.

On Jul, 11, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 53 people (0.03%) have International normalised ratio abnormal.

Could Zide cause International normalised ratio abnormal?

Among these 53 people:

How long have people been on Zide when they have International normalised ratio abnormal? *

What is the gender of people who have International normalised ratio abnormal when taking Zide? *

female: 57.14 %
male: 42.86 %

What is the age of people who have International normalised ratio abnormal when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides International normalised ratio abnormal? *

Weakness: 7 people, 13.21%
Abdominal Discomfort: 6 people, 11.32%
Fatigue (feeling of tiredness): 6 people, 11.32%
Oedema Peripheral (superficial swelling): 6 people, 11.32%
Chest Pain: 5 people, 9.43%
Kidney Stones: 5 people, 9.43%
Post Procedural Haemorrhage (post procedural bleeding): 4 people, 7.55%
Thrombocytopenia (decrease of platelets in blood): 4 people, 7.55%
Abdominal Pain: 4 people, 7.55%
Acute Kidney Failure: 4 people, 7.55%

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 14 people, 26.42%
Stress And Anxiety: 4 people, 7.55%
Pulmonary Embolism (blockage of the main artery of the lung): 4 people, 7.55%
Thrombosis (formation of a blood clot inside a blood vessel): 4 people, 7.55%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 7.55%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.66%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 5.66%
Primary Myelofibrosis (primary disorder of the bone marrow): 3 people, 5.66%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 5.66%
Cardiac Disorder: 2 people, 3.77%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have International normalised ratio abnormal?

- Check whether International normalised ratio abnormal is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

International normalised ratio abnormal treatments and more:

International normalised ratio abnormal (4,071 reports)

How severe was International normalised ratio abnormal and when was it recovered:

International normalised ratio abnormal in Zide

Expand to all the drugs that have ingredients of hydrochlorothiazide:

International normalised ratio abnormal and drugs with ingredients of hydrochlorothiazide

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with International normalised ratio abnormal:

International normalised ratio abnormal (329 drugs)

Browse all the conditions that are associated with International normalised ratio abnormal:

International normalised ratio abnormal (472 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.