Zide and Systolic dysfunction - a phase IV clinical study of FDA data

Summary:

Systolic dysfunction is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are male, 60+ old, also take Ramipril, and have Coronary heart disease.

The phase IV clinical study analyzes which people have Systolic dysfunction when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Systolic dysfunction?

Systolic dysfunction (impaired ventricular contraction) is found to be associated with 199 drugs and 218 conditions by eHealthMe. Check the latest studies of Systolic dysfunction.

On Jul, 10, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 42 people (0.02%) have Systolic dysfunction.

Among these 42 people:

What is the gender of people who have Systolic dysfunction when taking Zide? *

female: 7.69 %
male: 92.31 %

What is the age of people who have Systolic dysfunction when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Systolic dysfunction? *

Oedema Peripheral (superficial swelling): 35 people, 83.33%
Left Ventricular Dysfunction: 32 people, 76.19%
Mitral Valve Incompetence (inefficient heart valve): 31 people, 73.81%
Tricuspid Valve Incompetence (inefficient heart valve): 31 people, 73.81%
Fatigue (feeling of tiredness): 30 people, 71.43%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 30 people, 71.43%
Diastolic Dysfunction: 30 people, 71.43%
Rales (an abnormal respiratory sound characterized by fine crackles): 30 people, 71.43%
Left Ventricular Hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 29 people, 69.05%
Ejection Fraction Decreased (systolic heart failure): 29 people, 69.05%

What are the existing conditions these people have? *

Coronary Heart Disease (narrowing or blockage of the coronary arteries): 28 people, 66.67%
Acute Kidney Failure: 27 people, 64.29%
Cardiac Failure: 27 people, 64.29%
Carotid Arteriosclerosis (plaque deposition in artery): 27 people, 64.29%
Helicobacter Gastritis (inflammation of the inner lining of the stomach caused by helicobacter pylori (h. pylori) a bacterium): 18 people, 42.86%
Anaesthesia: 3 people, 7.14%
Drowsiness: 3 people, 7.14%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 7.14%
Left Ventricular Failure (left ventricle fails to contract forcefully): 2 people, 4.76%
Depression: 2 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Systolic dysfunction?

- Check whether Systolic dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systolic dysfunction:

Systolic dysfunction (199 drugs)

Browse all the conditions that are associated with Systolic dysfunction:

Systolic dysfunction (218 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.