Zide and Type iv hypersensitivity reaction - a phase IV clinical study of FDA data

Summary:

Type iv hypersensitivity reaction is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are male, 60+ old, also take Lamotrigine, and have Stroke.

The phase IV clinical study analyzes which people have Type iv hypersensitivity reaction when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Type iv hypersensitivity reaction?

Type iv hypersensitivity reaction (delayed type hypersensitivity as the reaction takes two to three days to develop) is found to be associated with 195 drugs and 415 conditions by eHealthMe. Check the latest studies of Type iv hypersensitivity reaction.

On Jul, 26, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 23 people (0.01%) have Type iv hypersensitivity reaction.

Could Zide cause Type iv hypersensitivity reaction?

Among these 23 people:

What is the gender of people who have Type iv hypersensitivity reaction when taking Zide? *

female: 38.1 %
male: 61.9 %

What is the age of people who have Type iv hypersensitivity reaction when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Type iv hypersensitivity reaction? *

Rashes (redness): 8 people, 34.78%
Weakness: 6 people, 26.09%
Hypotension (abnormally low blood pressure): 6 people, 26.09%
Rash Morbilliform (a rash that looks like measles): 5 people, 21.74%
General Physical Health Deterioration (weak health status): 5 people, 21.74%
Hemiparesis (weakness on one side of the body): 5 people, 21.74%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 4 people, 17.39%
Diarrhea: 3 people, 13.04%
Dermatitis Bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid): 2 people, 8.70%
Intestinal Villi Atrophy (erosion of the tiny villi in the intestines that help in absorb nutrients): 2 people, 8.70%

What are the existing conditions these people have? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 5 people, 21.74%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.04%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 8.70%
Depression: 2 people, 8.70%
Dyslipidaemia (abnormal amount of lipids): 2 people, 8.70%
Enlarged Prostate: 2 people, 8.70%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 4.35%
Asthma: 1 person, 4.35%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 4.35%
Diabetes: 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Type iv hypersensitivity reaction?

- Check whether Type iv hypersensitivity reaction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Type iv hypersensitivity reaction:

Type iv hypersensitivity reaction (195 drugs)

Browse all the conditions that are associated with Type iv hypersensitivity reaction:

Type iv hypersensitivity reaction (415 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.