1. Home
  2. Analysis
  3. Zoladex
  4. Osteoporosis

Zoladex and Osteoporosis - a phase IV clinical study of FDA data

Summary:

Osteoporosis is reported as a side effect among people who take Zoladex (goserelin acetate), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Zometa, and have Breast cancer metastatic.

The phase IV clinical study analyzes which people have Osteoporosis when taking Zoladex. It is created by eHealthMe based on reports of 13,593 people who have side effects when taking Zoladex from the FDA, and is updated regularly.

What is Zoladex?

Zoladex has active ingredients of goserelin acetate. It is often used in prostate cancer. eHealthMe is studying from 13,870 Zoladex users. Check the latest studies of Zoladex.

What is Osteoporosis?

Osteoporosis (bones weak and more likely to break) is found to be associated with 1,806 drugs and 1,905 conditions by eHealthMe. Check the latest studies of Osteoporosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

13,593 people reported to have side effects when taking Zoladex.
Among them, 94 people (0.69%) have Osteoporosis.

Could Zoladex cause Osteoporosis?

Among these 94 people:

How long have people been on Zoladex when they have Osteoporosis? *

  • < 1 month: 11.11 %
  • 1 - 6 months: 5.56 %
  • 6 - 12 months: 5.56 %
  • 1 - 2 years: 61.11 %
  • 2 - 5 years: 11.11 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 5.56 %

What is the gender of people who have Osteoporosis when taking Zoladex? *

  • female: 32.97 %
  • male: 67.03 %

What is the age of people who have Osteoporosis when taking Zoladex? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 7.32 %
  • 40-49: 13.41 %
  • 50-59: 15.85 %
  • 60+: 63.41 %

What are other drugs people take besides Zoladex? *

  1. Zometa: 29 people, 30.85%
  2. Casodex: 26 people, 27.66%
  3. Aredia: 16 people, 17.02%
  4. Lupron: 12 people, 12.77%
  5. Taxotere: 12 people, 12.77%
  6. Lipitor: 12 people, 12.77%
  7. Dexamethasone: 12 people, 12.77%
  8. Ketoconazole: 10 people, 10.64%
  9. Celebrex: 10 people, 10.64%
  10. Zyrtec: 10 people, 10.64%

What are other side effects people have besides Osteoporosis? *

  1. Pain: 36 people, 38.30%
  2. Bone Pain: 31 people, 32.98%
  3. Stress And Anxiety: 27 people, 28.72%
  4. Joint Pain: 24 people, 25.53%
  5. Weakness: 23 people, 24.47%
  6. Depression: 22 people, 23.40%
  7. Fatigue (feeling of tiredness): 21 people, 22.34%
  8. Osteonecrosis Of Jaw (death of bone of jaw): 20 people, 21.28%
  9. Bone Disorder: 19 people, 20.21%
  10. Pleural Effusion (water on the lungs): 19 people, 20.21%

What are the existing conditions these people have? *

  1. Breast Cancer Metastatic: 10 people, 10.64%
  2. Dyspnea (difficult or laboured breathing): 5 people, 5.32%
  3. High Blood Pressure: 3 people, 3.19%
  4. Arrhythmias (irregular heartbeat): 3 people, 3.19%
  5. Bipolar Disorder (mood disorder): 3 people, 3.19%
  6. Diabetes: 3 people, 3.19%
  7. Temporomandibular Joint Syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress): 3 people, 3.19%
  8. Neoplasm Malignant (cancer tumour): 3 people, 3.19%
  9. Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 2.13%
  10. Gastritis (inflammation of stomach): 2 people, 2.13%

* Approximation only. Some reports may have incomplete information.

Do you take Zoladex and have Osteoporosis?

- Check whether Osteoporosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoladex:

Osteoporosis treatments and more:

How severe was Osteoporosis and when was it recovered:

Expand to all the drugs that have ingredients of goserelin acetate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zoladex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoporosis:

Browse all the conditions that are associated with Osteoporosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on goserelin acetate (the active ingredients of Zoladex) and Zoladex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.