Zoledronic acid and Lymphoedema - a phase IV clinical study of FDA data

Summary:

Lymphoedema is reported as a side effect among people who take Zoledronic acid (zoledronic acid), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Letrozole, and have Breast cancer metastatic.

The phase IV clinical study analyzes which people have Lymphoedema when taking Zoledronic acid. It is created by eHealthMe based on reports of 28,440 people who have side effects when taking Zoledronic acid from the FDA, and is updated regularly.

What is Zoledronic acid?

Zoledronic acid has active ingredients of zoledronic acid. eHealthMe is studying from 28,485 Zoledronic acid users. Check the latest studies of Zoledronic acid.

What is Lymphoedema?

Lymphoedema (localized fluid retention and tissue swelling) is found to be associated with 911 drugs and 743 conditions by eHealthMe. Check the latest studies of Lymphoedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

28,440 people reported to have side effects when taking Zoledronic acid.
Among them, 50 people (0.18%) have Lymphoedema.

Could Zoledronic acid cause Lymphoedema?

Among these 50 people:

How long have people been on Zoledronic acid when they have Lymphoedema? *

What is the gender of people who have Lymphoedema when taking Zoledronic acid? *

female: 93.02 %
male: 6.98 %

What is the age of people who have Lymphoedema when taking Zoledronic acid? *

What are other drugs people take besides Zoledronic acid? *

What are other side effects people have besides Lymphoedema? *

Diarrhea: 16 people, 32.00%
Rashes (redness): 14 people, 28.00%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 14 people, 28.00%
White Blood Cell Count Decreased: 12 people, 24.00%
High Blood Pressure: 9 people, 18.00%
Back Pain: 8 people, 16.00%
Constipation: 8 people, 16.00%
Fever: 8 people, 16.00%
Haemoglobin Decreased: 8 people, 16.00%
Metastases To Bone (cancer spreads to bone): 8 people, 16.00%

What are the existing conditions these people have? *

Breast Cancer Metastatic: 25 people, 50.00%
Breast Cancer: 9 people, 18.00%
Diarrhea: 7 people, 14.00%
Pain: 6 people, 12.00%
Headache (pain in head): 5 people, 10.00%
Metastases To Bone (cancer spreads to bone): 4 people, 8.00%
Breast Cancer Female: 4 people, 8.00%
Diabetes: 2 people, 4.00%
Seasonal Allergy (allergic condition due to certain season): 2 people, 4.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Zoledronic acid and have Lymphoedema?

- Check whether Lymphoedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoledronic acid:

Zoledronic acid (28,485 reports)

Lymphoedema treatments and more:

Lymphoedema (9,453 reports)

Browse all side effects of Zoledronic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lymphoedema:

Lymphoedema (911 drugs)

Browse all the conditions that are associated with Lymphoedema:

Lymphoedema (743 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid (the active ingredients of Zoledronic acid) and Zoledronic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.