Zoloft and Bipolar ii disorder - a phase IV clinical study of FDA data

Summary:

Bipolar ii disorder is reported as a side effect among people who take Zoloft (sertraline hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years also take Effexor, and have Insomnia.

The phase IV clinical study analyzes which people have Bipolar ii disorder when taking Zoloft. It is created by eHealthMe based on reports of 128,159 people who have side effects when taking Zoloft from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,801 Zoloft users. Check the latest studies of Zoloft.

What is Bipolar ii disorder?

Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression) is found to be associated with 91 drugs and 360 conditions by eHealthMe. Check the latest studies of Bipolar ii disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

128,159 people reported to have side effects when taking Zoloft.
Among them, 16 people (0.01%) have Bipolar ii disorder.

Among these 16 people:

How long have people been on Zoloft when they have Bipolar ii disorder? *

What is the gender of people who have Bipolar ii disorder when taking Zoloft? *

female: 93.75 %
male: 6.25 %

What is the age of people who have Bipolar ii disorder when taking Zoloft? *

What are other drugs people take besides Zoloft? *

What are other side effects people have besides Bipolar ii disorder? *

Suicidal Ideation: 7 people, 43.75%
Agitation (state of anxiety or nervous excitement): 5 people, 31.25%
Insomnia (sleeplessness): 5 people, 31.25%
Memory Loss: 4 people, 25.00%
Mood Swings (an extreme or rapid change in mood): 4 people, 25.00%
Thinking Abnormal: 4 people, 25.00%
Feeling Abnormal: 3 people, 18.75%
Impulsive Behavior: 3 people, 18.75%
Sleep Disorder: 3 people, 18.75%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 3 people, 18.75%

What are the existing conditions these people have? *

Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 3 people, 18.75%
Insomnia (sleeplessness): 3 people, 18.75%
Sleep Disorder: 2 people, 12.50%
Mood Swings (an extreme or rapid change in mood): 2 people, 12.50%
Migraine (headache): 2 people, 12.50%
Ill-Defined Disorder: 2 people, 12.50%
Headache (pain in head): 2 people, 12.50%
Affective Disorder (mental disorder): 2 people, 12.50%
Adjustment Disorder: 2 people, 12.50%
Post-Traumatic Stress Disorder: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and have Bipolar ii disorder?

- Check whether Bipolar ii disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoloft:

Zoloft (138,801 reports)

Browse all side effects of Zoloft:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bipolar ii disorder:

Bipolar ii disorder (91 drugs)

Browse all the conditions that are associated with Bipolar ii disorder:

Bipolar ii disorder (360 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Zoloft) and Zoloft (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.