Zoloft and Canker sores - a phase IV clinical study of FDA data

Summary:

Canker sores is reported as a side effect among people who take Zoloft (sertraline hydrochloride), especially for people who are female, 30-39 old, also take Inflectra, and have Crohn's disease.

The phase IV clinical study analyzes which people have Canker sores when taking Zoloft. It is created by eHealthMe based on reports of 128,159 people who have side effects when taking Zoloft from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Canker sores?

Canker sores (painful, open sore in the mouth) is found to be associated with 613 drugs and 1,226 conditions by eHealthMe. Check the latest studies of Canker sores.

On May, 25, 2026

128,159 people reported to have side effects when taking Zoloft.
Among them, 31 people (0.02%) have Canker sores.

Among these 31 people:

What is the gender of people who have Canker sores when taking Zoloft? *

female: 89.47 %
male: 10.53 %

What is the age of people who have Canker sores when taking Zoloft? *

What are other drugs people take besides Zoloft? *

What are other side effects people have besides Canker sores? *

Headache (pain in head): 20 people, 64.52%
Malaise (a feeling of general discomfort or uneasiness): 15 people, 48.39%
Joint Pain: 14 people, 45.16%
Urinary Tract Infection: 13 people, 41.94%
Nausea (feeling of having an urge to vomit): 12 people, 38.71%
Weakness: 12 people, 38.71%
Drowsiness: 11 people, 35.48%
Fatigue (feeling of tiredness): 11 people, 35.48%
Dizziness: 10 people, 32.26%
Weight Increased: 9 people, 29.03%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 12 people, 38.71%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 25.81%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 22.58%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 9.68%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 3.23%
Renal Cancer Stage Iv (the tumour has spread to areas beyond gerota's fascia and extends into the adrenal gland on the same side of the body as the tumour, possibly to lymph nodes, but not to other parts of the body): 1 person, 3.23%
Gastrointestinal Stromal Tumor: 1 person, 3.23%
Drug Dependence: 1 person, 3.23%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 1 person, 3.23%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and have Canker sores?

- Check whether Canker sores is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoloft:

Zoloft (138,798 reports)

Canker sores treatments and more:

Canker sores (9,953 reports)

Browse all side effects of Zoloft:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Canker sores:

Canker sores (613 drugs)

Browse all the conditions that are associated with Canker sores:

Canker sores (1,226 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Zoloft) and Zoloft (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.