Zoloft and Endocarditis - a phase IV clinical study of FDA data

Summary:

Endocarditis is reported as a side effect among people who take Zoloft (sertraline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Prilosec, and have High blood pressure.

The phase IV clinical study analyzes which people have Endocarditis when taking Zoloft. It is created by eHealthMe based on reports of 128,159 people who have side effects when taking Zoloft from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Endocarditis?

Endocarditis (inflammation in heart muscle) is found to be associated with 660 drugs and 819 conditions by eHealthMe. Check the latest studies of Endocarditis.

On Jul, 10, 2026

128,159 people reported to have side effects when taking Zoloft.
Among them, 28 people (0.02%) have Endocarditis.

Among these 28 people:

How long have people been on Zoloft when they have Endocarditis? *

What is the gender of people who have Endocarditis when taking Zoloft? *

female: 60.71 %
male: 39.29 %

What is the age of people who have Endocarditis when taking Zoloft? *

What are other drugs people take besides Zoloft? *

What are other side effects people have besides Endocarditis? *

Fatigue (feeling of tiredness): 10 people, 35.71%
Nausea (feeling of having an urge to vomit): 7 people, 25.00%
Fever: 7 people, 25.00%
Abdominal Pain: 5 people, 17.86%
Weight Decreased: 5 people, 17.86%
Oedema Peripheral (superficial swelling): 5 people, 17.86%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 17.86%
Pneumonia: 5 people, 17.86%
Dyspnea (difficult or laboured breathing): 5 people, 17.86%
Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 17.86%

What are the existing conditions these people have? *

Pain: 4 people, 14.29%
High Blood Pressure: 4 people, 14.29%
High Blood Cholesterol: 3 people, 10.71%
Cardiac Failure: 2 people, 7.14%
Reflux Gastritis (a condition in which the lining of a person's stomach becomes inflamed as a result of exposure to bile): 1 person, 3.57%
Hypersensitivity: 1 person, 3.57%
Blood Phosphorus Increased: 1 person, 3.57%
Cardiac Failure Acute: 1 person, 3.57%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 3.57%
Dyslipidaemia (abnormal amount of lipids): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and have Endocarditis?

- Check whether Endocarditis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoloft:

Zoloft (138,798 reports)

Endocarditis treatments and more:

Endocarditis (9,259 reports)

Browse all side effects of Zoloft:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Endocarditis:

Endocarditis (660 drugs)

Browse all the conditions that are associated with Endocarditis:

Endocarditis (819 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Zoloft) and Zoloft (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.