Zoloft and Febrile bone marrow aplasia - a phase IV clinical study of FDA data

Summary:

Febrile bone marrow aplasia is reported as a side effect among people who take Zoloft (sertraline hydrochloride), especially for people who are female, 60+ old, also take Neurontin, and have Sarcoma metastatic.

The phase IV clinical study analyzes which people have Febrile bone marrow aplasia when taking Zoloft. It is created by eHealthMe based on reports of 128,159 people who have side effects when taking Zoloft from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,801 Zoloft users. Check the latest studies of Zoloft.

What is Febrile bone marrow aplasia?

Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells) is found to be associated with 294 drugs and 466 conditions by eHealthMe. Check the latest studies of Febrile bone marrow aplasia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

128,159 people reported to have side effects when taking Zoloft.
Among them, 12 people (0.01%) have Febrile bone marrow aplasia.

Could Zoloft cause Febrile bone marrow aplasia?

Among these 12 people:

What is the gender of people who have Febrile bone marrow aplasia when taking Zoloft? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Febrile bone marrow aplasia when taking Zoloft? *

What are other drugs people take besides Zoloft? *

What are other side effects people have besides Febrile bone marrow aplasia? *

Nausea And Vomiting: 6 people, 50.00%
Weight Decreased: 5 people, 41.67%
Febrile Neutropenia (fever with reduced white blood cells): 5 people, 41.67%
Mucosal Inflammation (infection of mucous membrane): 5 people, 41.67%
Rashes (redness): 2 people, 16.67%
Acute Coronary Syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 2 people, 16.67%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 1 person, 8.33%
Rash Maculo-Papular (red area on the skin that is covered with small confluent bumps): 1 person, 8.33%
Blood Creatinine Increased: 1 person, 8.33%
Bronchial Secretion Retention: 1 person, 8.33%

What are the existing conditions these people have? *

Sarcoma Metastatic (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues spreads to other parts): 5 people, 41.67%
Tracheobronchitis (an inflammation or infection, which affects the trachea and bronchi of respiratory tract): 1 person, 8.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 8.33%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 8.33%
Multiple Myeloma (cancer of the plasma cells): 1 person, 8.33%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 1 person, 8.33%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and have Febrile bone marrow aplasia?

- Check whether Febrile bone marrow aplasia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoloft:

Zoloft (138,801 reports)

Browse all side effects of Zoloft:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Febrile bone marrow aplasia:

Febrile bone marrow aplasia (294 drugs)

Browse all the conditions that are associated with Febrile bone marrow aplasia:

Febrile bone marrow aplasia (466 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Zoloft) and Zoloft (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.