Zoloft and Frustration - a phase IV clinical study of FDA data

Summary:

Frustration is reported as a side effect among people who take Zoloft (sertraline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Wellbutrin, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Frustration when taking Zoloft. It is created by eHealthMe based on reports of 128,159 people who have side effects when taking Zoloft from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Frustration?

Frustration (a form of poorly expressed anger) is found to be associated with 382 drugs and 621 conditions by eHealthMe. Check the latest studies of Frustration.

On Jul, 19, 2026

128,159 people reported to have side effects when taking Zoloft.
Among them, 82 people (0.06%) have Frustration.

Among these 82 people:

How long have people been on Zoloft when they have Frustration? *

What is the gender of people who have Frustration when taking Zoloft? *

female: 58.23 %
male: 41.77 %

What is the age of people who have Frustration when taking Zoloft? *

What are other drugs people take besides Zoloft? *

What are other side effects people have besides Frustration? *

Fatigue (feeling of tiredness): 21 people, 25.61%
Irritability: 16 people, 19.51%
Anger: 16 people, 19.51%
Insomnia (sleeplessness): 15 people, 18.29%
Memory Loss: 13 people, 15.85%
Drug Ineffective: 13 people, 15.85%
Feeling Abnormal: 12 people, 14.63%
Agitation (state of anxiety or nervous excitement): 11 people, 13.41%
Speech Disorder: 10 people, 12.20%
High Blood Pressure: 9 people, 10.98%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 10.98%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 8 people, 9.76%
Pain: 6 people, 7.32%
Asthma: 5 people, 6.10%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 4 people, 4.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 4.88%
High Blood Pressure: 4 people, 4.88%
Quit Smoking: 4 people, 4.88%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 3.66%
Osteoporosis (bones weak and more likely to break): 3 people, 3.66%

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and have Frustration?

- Check whether Frustration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoloft:

Zoloft (138,798 reports)

Frustration treatments and more:

Frustration (4,545 reports)

Browse all side effects of Zoloft:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Frustration:

Frustration (382 drugs)

Browse all the conditions that are associated with Frustration:

Frustration (621 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Zoloft) and Zoloft (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.