Zoloft and Middle ear effusion - a phase IV clinical study of FDA data

Summary:

Middle ear effusion is reported as a side effect among people who take Zoloft (sertraline hydrochloride), especially for people who are female, 50-59 old, also take Aspirin, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Middle ear effusion when taking Zoloft. It is created by eHealthMe based on reports of 128,159 people who have side effects when taking Zoloft from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Middle ear effusion?

Middle ear effusion (fluid in middle ear) is found to be associated with 333 drugs and 446 conditions by eHealthMe. Check the latest studies of Middle ear effusion.

On Jul, 13, 2026

128,159 people reported to have side effects when taking Zoloft.
Among them, 21 people (0.02%) have Middle ear effusion.

Among these 21 people:

What is the gender of people who have Middle ear effusion when taking Zoloft? *

female: 61.9 %
male: 38.1 %

What is the age of people who have Middle ear effusion when taking Zoloft? *

What are other drugs people take besides Zoloft? *

What are other side effects people have besides Middle ear effusion? *

Headache (pain in head): 8 people, 38.10%
Fall: 7 people, 33.33%
Dizziness: 7 people, 33.33%
Nausea (feeling of having an urge to vomit): 6 people, 28.57%
Rashes (redness): 6 people, 28.57%
Cough: 6 people, 28.57%
Chest Pain: 6 people, 28.57%
High Blood Pressure: 6 people, 28.57%
Balance Disorder: 6 people, 28.57%
Dehydration (dryness resulting from the removal of water): 6 people, 28.57%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 19.05%
High Blood Pressure: 3 people, 14.29%
Hepatitis C: 3 people, 14.29%
Itching: 2 people, 9.52%
Bone Loss: 2 people, 9.52%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 9.52%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 9.52%
Drowsiness: 2 people, 9.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.52%
Glaucoma (increased fluid pressure in the eye with vision loss): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and have Middle ear effusion?

- Check whether Middle ear effusion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoloft:

Zoloft (138,798 reports)

Browse all side effects of Zoloft:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Middle ear effusion:

Middle ear effusion (333 drugs)

Browse all the conditions that are associated with Middle ear effusion:

Middle ear effusion (446 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Zoloft) and Zoloft (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.