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Zolpidem and Dysphoria - a phase IV clinical study of FDA data

Summary:

Dysphoria is reported as a side effect among people who take Zolpidem (zolpidem tartrate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Cymbalta, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Dysphoria when taking Zolpidem. It is created by eHealthMe based on reports of 90,339 people who have side effects when taking Zolpidem from the FDA, and is updated regularly.

What is Zolpidem?

Zolpidem has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 92,695 Zolpidem users. Check the latest studies of Zolpidem.

What is Dysphoria?

Dysphoria (generalized dissatisfaction with life) is found to be associated with 351 drugs and 534 conditions by eHealthMe. Check the latest studies of Dysphoria.

On Jul, 17, 2026

90,339 people reported to have side effects when taking Zolpidem.
Among them, 48 people (0.05%) have Dysphoria.

Could Zolpidem cause Dysphoria?

Among these 48 people:

How long have people been on Zolpidem when they have Dysphoria? *

  • < 1 month: 90.91 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 9.09 %
  • 10+ years: 0.0 %

What is the gender of people who have Dysphoria when taking Zolpidem? *

  • female: 53.19 %
  • male: 46.81 %

What is the age of people who have Dysphoria when taking Zolpidem? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 4.76 %
  • 20-29: 2.38 %
  • 30-39: 14.29 %
  • 40-49: 23.81 %
  • 50-59: 9.52 %
  • 60+: 45.24 %

What are other drugs people take besides Zolpidem? *

  1. Cymbalta: 9 people, 18.75%
  2. Nexium: 6 people, 12.50%
  3. Akineton: 6 people, 12.50%
  4. Amlodipine: 6 people, 12.50%
  5. Movicol: 5 people, 10.42%
  6. Prilosec: 4 people, 8.33%
  7. Xanax: 4 people, 8.33%
  8. Alprazolam: 4 people, 8.33%
  9. Diazepam: 4 people, 8.33%
  10. Crestor: 4 people, 8.33%

What are other side effects people have besides Dysphoria? *

  1. Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 19 people, 39.58%
  2. Stress And Anxiety: 18 people, 37.50%
  3. Irritability: 17 people, 35.42%
  4. Nausea (feeling of having an urge to vomit): 16 people, 33.33%
  5. Drug Dependence: 15 people, 31.25%
  6. Suicidal Ideation: 15 people, 31.25%
  7. Confusional State: 14 people, 29.17%
  8. Fatigue (feeling of tiredness): 13 people, 27.08%
  9. Agitation (state of anxiety or nervous excitement): 11 people, 22.92%
  10. Hyperhidrosis (abnormally increased sweating): 10 people, 20.83%

What are the existing conditions these people have? *

  1. Stress And Anxiety: 13 people, 27.08%
  2. Depression: 12 people, 25.00%
  3. High Blood Pressure: 7 people, 14.58%
  4. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 6 people, 12.50%
  5. Back Pain: 5 people, 10.42%
  6. Bipolar Disorder (mood disorder): 5 people, 10.42%
  7. Partial Seizures (seizures which affect only a part of the brain at onset): 5 people, 10.42%
  8. Pain: 5 people, 10.42%
  9. Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 5 people, 10.42%
  10. Gastric Ulcer (stomach ulcer): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Zolpidem and have Dysphoria?

- Check whether Dysphoria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zolpidem:

Dysphoria treatments and more:

How severe was Dysphoria and when was it recovered:

Expand to all the drugs that have ingredients of zolpidem tartrate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zolpidem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dysphoria:

Browse all the conditions that are associated with Dysphoria:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on zolpidem tartrate (the active ingredients of Zolpidem) and Zolpidem (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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