Zosyn and Anaphylactoid reaction - a phase IV clinical study of FDA data

Summary:

Anaphylactoid reaction is reported as a side effect among people who take Zosyn (piperacillin sodium; tazobactam sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Cipro, and have Kidney infection (pyelonephritis).

The phase IV clinical study analyzes which people have Anaphylactoid reaction when taking Zosyn. It is created by eHealthMe based on reports of 10,175 people who have side effects when taking Zosyn from the FDA, and is updated regularly.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

What is Anaphylactoid reaction?

Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation) is found to be associated with 416 drugs and 723 conditions by eHealthMe. Check the latest studies of Anaphylactoid reaction.

On Jul, 13, 2026

10,175 people reported to have side effects when taking Zosyn.
Among them, 13 people (0.13%) have Anaphylactoid reaction.

Could Zosyn cause Anaphylactoid reaction?

Among these 13 people:

How long have people been on Zosyn when they have Anaphylactoid reaction? *

What is the gender of people who have Anaphylactoid reaction when taking Zosyn? *

female: 53.85 %
male: 46.15 %

What is the age of people who have Anaphylactoid reaction when taking Zosyn? *

What are other drugs people take besides Zosyn? *

What are other side effects people have besides Anaphylactoid reaction? *

Cough: 3 people, 23.08%
Chills (felling of cold): 2 people, 15.38%
Oropharyngeal Pain: 2 people, 15.38%
Skin Blushing/flushing (a sudden reddening of the face, neck): 2 people, 15.38%
Transaminases Increased: 1 person, 7.69%
Eyelid Oedema (eyelids are swollen and contain excessive fluid): 1 person, 7.69%
Asthma: 1 person, 7.69%
Blood Bilirubin Increased: 1 person, 7.69%
Clamminess (moist, sticky, and cold to the touch): 1 person, 7.69%
Drug Eruption (adverse drug reaction of the skin): 1 person, 7.69%

What are the existing conditions these people have? *

Kidney Infection (Pyelonephritis): 3 people, 23.08%
Stress Gastritis (swelling (inflammation) and weakening of the stomach lining that occurs during a serious illness): 1 person, 7.69%
Skin Ulcer: 1 person, 7.69%
Rashes (redness): 1 person, 7.69%
Pyelonephritis Acute (sudden inflammation of kidney caused by bacteria): 1 person, 7.69%
Peripheral Swelling: 1 person, 7.69%
Pain In Extremity: 1 person, 7.69%
Osteomyelitis (infection of bone): 1 person, 7.69%
Hypotension (abnormally low blood pressure): 1 person, 7.69%
Haematochezia (passage of stools containing blood): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Zosyn and have Anaphylactoid reaction?

- Check whether Anaphylactoid reaction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zosyn:

Zosyn (10,236 reports)

Anaphylactoid reaction treatments and more:

Anaphylactoid reaction (6,341 reports)

How severe was Anaphylactoid reaction and when was it recovered:

Anaphylactoid reaction in Zosyn

Expand to all the drugs that have ingredients of piperacillin sodium; tazobactam sodium:

Anaphylactoid reaction and drugs with ingredients of piperacillin sodium; tazobactam sodium (21 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zosyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anaphylactoid reaction:

Anaphylactoid reaction (416 drugs)

Browse all the conditions that are associated with Anaphylactoid reaction:

Anaphylactoid reaction (723 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on piperacillin sodium; tazobactam sodium (the active ingredients of Zosyn) and Zosyn (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.