Zyban and Malaise - a phase IV clinical study of FDA data

Summary:

Malaise is reported as a side effect among people who take Zyban (bupropion hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Ativan, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Malaise when taking Zyban. It is created by eHealthMe based on reports of 7,776 people who have side effects when taking Zyban from the FDA, and is updated regularly.

What is Zyban?

Zyban has active ingredients of bupropion hydrochloride. It is often used in quit smoking. eHealthMe is studying from 8,029 Zyban users. Check the latest studies of Zyban.

What is Malaise?

Malaise (a feeling of general discomfort or uneasiness) is found to be associated with 3,506 drugs and 5,120 conditions by eHealthMe. Check the latest studies of Malaise.

On Jul, 20, 2026

7,776 people reported to have side effects when taking Zyban.
Among them, 289 people (3.72%) have Malaise.

Among these 289 people:

* Approximation only. Some reports may have incomplete information.

Do you take Zyban and have Malaise?

- Check whether Malaise is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zyban:

Zyban (8,029 reports)

Malaise treatments and more:

Malaise (529,933 reports)

How severe was Malaise and when was it recovered:

Malaise in Zyban

Expand to all the drugs that have ingredients of bupropion hydrochloride:

Malaise and drugs with ingredients of bupropion hydrochloride (5,625 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zyban:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malaise:

Malaise (3,506 drugs)

Browse all the conditions that are associated with Malaise:

Malaise (5,120 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride (the active ingredients of Zyban) and Zyban (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.