Zyclara and Pain exacerbated - a phase IV clinical study of FDA data

Summary:

Pain exacerbated is reported as a side effect among people who take Zyclara (imiquimod), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Drospirenone And Ethinyl Estradiol, and have Actinic keratosis.

The phase IV clinical study analyzes which people have Pain exacerbated when taking Zyclara. It is created by eHealthMe based on reports of 449 people who have side effects when taking Zyclara from the FDA, and is updated regularly.

What is Zyclara?

Zyclara has active ingredients of imiquimod. eHealthMe is studying from 462 Zyclara users. Check the latest studies of Zyclara.

What is Pain exacerbated?

Pain exacerbated is found to be associated with 3,979 drugs and 3,033 conditions by eHealthMe. Check the latest studies of Pain exacerbated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

449 people reported to have side effects when taking Zyclara.
Among them, 20 people (4.45%) have Pain exacerbated.

Among these 20 people:

How long have people been on Zyclara when they have Pain exacerbated? *

What is the gender of people who have Pain exacerbated when taking Zyclara? *

female: 47.37 %
male: 52.63 %

What is the age of people who have Pain exacerbated when taking Zyclara? *

What are other drugs people take besides Zyclara? *

Yaz: 1 person, 5.00%
Yasmin: 1 person, 5.00%
Wellbutrin: 1 person, 5.00%
Vitamin D: 1 person, 5.00%
Tamsulosin: 1 person, 5.00%
Synthroid: 1 person, 5.00%
Magnesium: 1 person, 5.00%
Flonase: 1 person, 5.00%
Fish Oil: 1 person, 5.00%
Drospirenone And Ethinyl Estradiol: 1 person, 5.00%

What are other side effects people have besides Pain exacerbated? *

Influenza Like Illness: 8 people, 40.00%
Joint Pain: 5 people, 25.00%
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 5 people, 25.00%
Fatigue (feeling of tiredness): 5 people, 25.00%
Headache (pain in head): 4 people, 20.00%
Scab (a hard coating on the skin formed during the wound healing): 3 people, 15.00%
Nausea (feeling of having an urge to vomit): 3 people, 15.00%
Rashes (redness): 3 people, 15.00%
Fever: 3 people, 15.00%
Gastric Ulcer (stomach ulcer): 2 people, 10.00%

What are the existing conditions these people have? *

Actinic Keratosis (skin disease due to sun exposure): 9 people, 45.00%
Precancerous Skin Lesion: 4 people, 20.00%
Skin Cancer: 1 person, 5.00%
Pancreatic Enzymes Abnormal: 1 person, 5.00%
Lip Disorder (disease of lip): 1 person, 5.00%
Hypersensitivity: 1 person, 5.00%
Concussion (short loss of normal brain function in response to a head injury): 1 person, 5.00%
Bowen's Disease (early stage of skin cancer): 1 person, 5.00%
Basal Cell Carcinoma (a skin cancer, it rarely metastasizes or kills): 1 person, 5.00%
Asthma: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Zyclara and have Pain exacerbated?

- Check whether Pain exacerbated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zyclara:

Zyclara (462 reports)

Browse all side effects of Zyclara:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pain exacerbated:

Pain exacerbated (3,979 drugs)

Browse all the conditions that are associated with Pain exacerbated:

Pain exacerbated (3,033 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on imiquimod (the active ingredients of Zyclara) and Zyclara (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.