Zyrtec and Malignant pleural effusion - a phase IV clinical study of FDA data

Summary:

Malignant pleural effusion is reported as a side effect among people who take Zyrtec (cetirizine hydrochloride), especially for people who are female, 60+ old, also take Reglan, and have Breast cancer.

The phase IV clinical study analyzes which people have Malignant pleural effusion when taking Zyrtec. It is created by eHealthMe based on reports of 109,528 people who have side effects when taking Zyrtec from the FDA, and is updated regularly.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,620 Zyrtec users. Check the latest studies of Zyrtec.

What is Malignant pleural effusion?

Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung) is found to be associated with 356 drugs and 448 conditions by eHealthMe. Check the latest studies of Malignant pleural effusion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

109,528 people reported to have side effects when taking Zyrtec.
Among them, 14 people (0.01%) have Malignant pleural effusion.

Could Zyrtec cause Malignant pleural effusion?

Among these 14 people:

What is the gender of people who have Malignant pleural effusion when taking Zyrtec? *

female: 92.86 %
male: 7.14 %

What is the age of people who have Malignant pleural effusion when taking Zyrtec? *

What are other drugs people take besides Zyrtec? *

Ambien: 13 people, 92.86%
Reglan: 13 people, 92.86%
Zometa: 11 people, 78.57%
Mobic: 11 people, 78.57%
Aredia: 11 people, 78.57%
Ultram: 11 people, 78.57%
Celebrex: 11 people, 78.57%
Chlorhexidine Gluconate: 9 people, 64.29%
Tamoxifen Citrate: 8 people, 57.14%
Klonopin: 7 people, 50.00%

What are other side effects people have besides Malignant pleural effusion? *

Pain: 12 people, 85.71%
Bone Disorder: 11 people, 78.57%
Osteonecrosis Of Jaw (death of bone of jaw): 11 people, 78.57%
Osteomyelitis (infection of bone): 11 people, 78.57%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 11 people, 78.57%
Pathological Fracture (broken bone caused by disease): 11 people, 78.57%
Emotional Distress: 11 people, 78.57%
Hypoaesthesia (reduced sense of touch or sensation): 11 people, 78.57%
Cervical Spinal Stenosis (narrowing of the spinal canal in the neck): 11 people, 78.57%
Gums - Swollen: 11 people, 78.57%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 11 people, 78.57%
Breast Cancer: 11 people, 78.57%
Stress And Anxiety: 7 people, 50.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 50.00%
Breast Cancer Metastatic: 7 people, 50.00%
Bone Pain: 7 people, 50.00%
Osteomyelitis (infection of bone): 4 people, 28.57%
Bone Cancer Metastatic: 4 people, 28.57%
Colon Cancer: 1 person, 7.14%
Breast Cancer Stage Iv: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Zyrtec and have Malignant pleural effusion?

- Check whether Malignant pleural effusion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zyrtec:

Zyrtec (114,620 reports)

Browse all side effects of Zyrtec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malignant pleural effusion:

Malignant pleural effusion (356 drugs)

Browse all the conditions that are associated with Malignant pleural effusion:

Malignant pleural effusion (448 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cetirizine hydrochloride (the active ingredients of Zyrtec) and Zyrtec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.