Clozaril vs. Seroquel xr: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Clozaril and Seroquel xr. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 364,371 people who take Clozaril and Seroquel xr, and is updated regularly.
What is Clozaril?
Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 65,127 Clozaril users. Check the latest studies of Clozaril.
What is Seroquel xr?
Seroquel xr has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 11,825 Seroquel xr users. Check the latest studies of Seroquel xr.
364,371 people who take Clozaril and Seroquel xr are studied.

Drugs being compared in this study:
- Clozaril (clozapine)
- Seroquel Xr (quetiapine fumarate)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Clozaril:
- not at all: 4.45 %
- somewhat: 21.86 %
- moderate: 27.13 %
- high: 32.39 %
- very high: 14.17 %
Seroquel Xr:
- not at all: 4.78 %
- somewhat: 20.66 %
- moderate: 30.59 %
- high: 30.17 %
- very high: 13.8 %
Want to compare Clozaril with Seroquel xr?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Mati?, K., & Pele?, A. M. , "Drug-induced toxic hepatitis associated with the combination of quetiapine and fluphenazine: A case report", The European Journal of Psychiatry, 2018 Jan .
- Shah Z, Londhe V, "Influence of various media on the dissolution profiles of immediate-release quetiapine tablets in India", Dissolution Technologies, 2016 Feb .
- Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
- Yaylaci S, Yilmaz EU, Guclu E, Kumsar NA, Tamer A, Karabay O, "Clozapine-Induced Febrile Neutropenia and Cellulitis", Turkish journal of emergency medicine, 2014 Mar .
- Mati?, K., & Pele?, A. M. , "Drug-induced toxic hepatitis associated with the combination of quetiapine and fluphenazine: A case report", The European Journal of Psychiatry, 2018 Jan .
- Shah Z, Londhe V, "Influence of various media on the dissolution profiles of immediate-release quetiapine tablets in India", Dissolution Technologies, 2016 Feb .
- Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
- Yaylaci S, Yilmaz EU, Guclu E, Kumsar NA, Tamer A, Karabay O, "Clozapine-Induced Febrile Neutropenia and Cellulitis", Turkish journal of emergency medicine, 2014 Mar .
Related studies
Alternative drugs to, pros and cons of:
- Clozaril (64,962 reports)
- Seroquel xr (10,588 reports)
Browse all side effects of Clozaril:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Seroquel xr:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on clozapine and quetiapine fumarate (the active ingredients of Clozaril and Seroquel xr, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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