Duloxetine hydrochloride vs. Lexapro: side effect and effectiveness comparison (a real world drug study)

Summary:

We compare the side effects and drug effectiveness of Duloxetine hydrochloride and Lexapro. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 382,393 people who take Duloxetine hydrochloride and Lexapro, and is updated regularly.

What is Duloxetine hydrochloride?

Duloxetine hydrochloride has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 17,410 Duloxetine hydrochloride users. Check the latest studies of Duloxetine hydrochloride.

What is Lexapro?

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 91,464 Lexapro users. Check the latest studies of Lexapro.



On May, 28, 2026

382,393 people who take Duloxetine hydrochloride and Lexapro are studied.

Duloxetine hydrochloride vs Lexapro drug comparison reports.

Drugs being compared in this study:

  • Duloxetine Hydrochloride (duloxetine hydrochloride)
  • Lexapro (escitalopram oxalate)

Most common side effects of the drugs, overall:

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Most common side effects of the drugs, in long term (1+ years) use:

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Drug effectiveness:

Duloxetine Hydrochloride:

  • not at all: 5.11 %
  • somewhat: 24.38 %
  • moderate: 35.79 %
  • high: 26.22 %
  • very high: 8.5 %

Lexapro:

  • not at all: 3.95 %
  • somewhat: 19.05 %
  • moderate: 37.02 %
  • high: 29.83 %
  • very high: 10.15 %

Want to compare Duloxetine hydrochloride with Lexapro?

- Personalize this study to your gender and age (0-99+)

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.



Related publications that referenced our studies

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Alternative drugs to, pros and cons of:

Browse all side effects of Duloxetine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Lexapro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study is based on duloxetine hydrochloride and escitalopram oxalate (the active ingredients of Duloxetine hydrochloride and Lexapro, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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