Escitalopram vs. Sertraline hydrochloride: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Escitalopram and Sertraline hydrochloride. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 448,179 people who take Escitalopram and Sertraline hydrochloride, and is updated regularly.
What is Escitalopram?
Escitalopram has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 78,081 Escitalopram users. Check the latest studies of Escitalopram.
What is Sertraline hydrochloride?
Sertraline hydrochloride has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 28,199 Sertraline hydrochloride users. Check the latest studies of Sertraline hydrochloride.
448,179 people who take Escitalopram and Sertraline hydrochloride are studied.

Drugs being compared in this study:
- Escitalopram (escitalopram oxalate)
- Sertraline Hydrochloride (sertraline hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Escitalopram:
- not at all: 3.76 %
- somewhat: 19.73 %
- moderate: 36.61 %
- high: 29.35 %
- very high: 10.54 %
Sertraline Hydrochloride:
- not at all: 3.49 %
- somewhat: 19.77 %
- moderate: 36.33 %
- high: 30.87 %
- very high: 9.55 %
Want to compare Escitalopram with Sertraline hydrochloride?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
- Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
- Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Related studies
Alternative drugs to, pros and cons of:
- Escitalopram (75,146 reports)
- Sertraline hydrochloride (25,999 reports)
Browse all side effects of Escitalopram:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Sertraline hydrochloride:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on escitalopram oxalate and sertraline hydrochloride (the active ingredients of Escitalopram and Sertraline hydrochloride, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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