Guanfacine hydrochloride vs. Modafinil: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Guanfacine hydrochloride and Modafinil. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 55,097 people who take Guanfacine hydrochloride and Modafinil, and is updated regularly.
What is Guanfacine hydrochloride?
Guanfacine hydrochloride has active ingredients of guanfacine hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 1,216 Guanfacine hydrochloride users. Check the latest studies of Guanfacine hydrochloride.
What is Modafinil?
Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.
55,097 people who take Guanfacine hydrochloride and Modafinil are studied.

Drugs being compared in this study:
- Modafinil (modafinil)
- Guanfacine Hydrochloride (guanfacine hydrochloride)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Guanfacine Hydrochloride:
- not at all: 6.93 %
- somewhat: 31.02 %
- moderate: 39.37 %
- high: 17.32 %
- very high: 5.35 %
Modafinil:
- not at all: 2.81 %
- somewhat: 17.62 %
- moderate: 33.25 %
- high: 32.12 %
- very high: 14.19 %
Want to compare Guanfacine hydrochloride with Modafinil?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
- Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
Related studies
Alternative drugs to, pros and cons of:
- Guanfacine hydrochloride (861 reports)
- Modafinil (19,892 reports)
Browse all side effects of Guanfacine hydrochloride:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Modafinil:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on guanfacine hydrochloride and modafinil (the active ingredients of Guanfacine hydrochloride and Modafinil, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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