Methadone hydrochloride vs. Acetaminophen and codeine phosphate: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Methadone hydrochloride and Acetaminophen and codeine phosphate. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 111,723 people who take Methadone hydrochloride and Acetaminophen and codeine phosphate, and is updated regularly.
What is Methadone hydrochloride?
Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 8,598 Methadone hydrochloride users. Check the latest studies of Methadone hydrochloride.
What is Acetaminophen and codeine phosphate?
Acetaminophen and codeine phosphate has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 3,220 Acetaminophen and codeine phosphate users. Check the latest studies of Acetaminophen and codeine phosphate.
eHealthMe: drug outcomes in the real world
eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.
111,723 people who take Methadone hydrochloride and Acetaminophen and codeine phosphate are studied.

Drugs being compared in this study:
- Methadone Hydrochloride (methadone hydrochloride)
- Acetaminophen And Codeine Phosphate (acetaminophen; codeine phosphate)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Methadone Hydrochloride:
- not at all: 1.9 %
- somewhat: 14.8 %
- moderate: 31.72 %
- high: 31.72 %
- very high: 19.86 %
Acetaminophen And Codeine Phosphate:
- not at all: 3.38 %
- somewhat: 27.61 %
- moderate: 39.44 %
- high: 22.63 %
- very high: 6.95 %
Want to compare Methadone hydrochloride with Acetaminophen and codeine phosphate?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
Related studies
Alternative drugs to, pros and cons of:
- Methadone hydrochloride (6,739 reports)
- Acetaminophen and codeine phosphate (2,908 reports)
Browse all side effects of Methadone hydrochloride:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Acetaminophen and codeine phosphate:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on methadone hydrochloride and acetaminophen; codeine phosphate (the active ingredients of Methadone hydrochloride and Acetaminophen and codeine phosphate, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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