Modafinil vs. Advil pm: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Modafinil and Advil pm. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 47,728 people who take Modafinil and Advil pm, and is updated regularly.
What is Modafinil?
Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.
What is Advil pm?
Advil pm has active ingredients of diphenhydramine hydrochloride; ibuprofen. It is often used in insomnia. eHealthMe is studying from 1,445 Advil pm users. Check the latest studies of Advil pm.
47,728 people who take Modafinil and Advil pm are studied.

Drugs being compared in this study:
- Advil Pm (diphenhydramine hydrochloride; ibuprofen)
- Modafinil (modafinil)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Modafinil:
- not at all: 2.86 %
- somewhat: 17.48 %
- moderate: 33.58 %
- high: 31.84 %
- very high: 14.24 %
Advil Pm:
- not at all: 4.05 %
- somewhat: 19.59 %
- moderate: 53.38 %
- high: 15.54 %
- very high: 7.43 %
Want to compare Modafinil with Advil pm?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
- Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
Related studies
Alternative drugs to, pros and cons of:
Browse all side effects of Modafinil:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Advil pm:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on modafinil and diphenhydramine hydrochloride; ibuprofen (the active ingredients of Modafinil and Advil pm, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Recent studies on eHealthMe:
- Could Januvia cause Insulin Resistance? - 13 seconds ago
- Drug interactions of Leflunomide and Fluocinonide - 15 seconds ago
- Could Fluoxetine cause Acute Respiratory Failure? - 21 seconds ago
- Drug interactions of Clorazepate Dipotassium and Hydrochlorothiazide - 27 seconds ago
- Could Embolex cause Alanine Aminotransferase Increased? - 27 seconds ago
- Could Amoxicillin cause Vomiting Aggravated? - 28 seconds ago
- Could Zantac cause Liver Disorder? - 29 seconds ago
- Could Sodium Bicarbonate cause Heart Attack? - 29 seconds ago
- Could Pravastatin Sodium cause Asthma? - 30 seconds ago
- Could Temazepam cause Sleep Terror? - 34 seconds ago